Evidence map›Paper›PMID 34660875›Full record

ArticleSSM - population health2021

Allostatic load, unhealthy behaviors, and depressive symptoms in the Hispanic Community Health Study/Study of Latinos.

Erik J Rodriquez, Saida I Coreas, Linda C Gallo, Carmen R Isasi, Christian R Salazar, Frank C Bandiera, Shakira F Suglia, Krista M Perreira, Rosalba Hernandez, Frank Penedo and 3 more

Open access · goldAbstract read
In one paragraph

Article in SSM - population health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Discussing the Interplay of Social Determinants of Health, Aging, and Alzheimer's Biomarkers in U.S. Latinos.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Review
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Erik J RodriquezDivision of Intramural Research; National Heart, Lung, And Blood Institute; 3 Center Drive, Bethesda, MD, 20892-0311, USA.
Saida I CoreasDivision of Intramural Research; National Heart, Lung, And Blood Institute; 3 Center Drive, Bethesda, MD, 20892-0311, USA.
Linda C GalloDepartment of Psychology, San Diego State University, 780 Bay Boulevard Suite 200, Chula Vista, CA, 91910, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Christian R SalazarUC Irvine Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, 3227 Biological Sciences III, Irvine, CA, 92697, USA.
Frank C BandieraDivision of Behavioral and Social Research, National Institute on Aging, 31 Center Drive, Bethesda, MD, 20892-2292, USA.
Shakira F SugliaRollins School of Public Health, Emory University, 201 Dowman Drive, Atlanta, GA, 30322, USA.
Krista M PerreiraSchool of Medicine, University of North Carolina, 333 South Columbia Street, Chapel Hill, NC, 27599-7240, USA.
Rosalba HernandezSchool of Social Work, University of Illinois at Urbana-Champaign, 1010 West Nevada Street, Urbana, IL, 61801, USA.
Frank PenedoDepartment of Psychology, University of Miami, Flipse Building, 5th Floor, 5665 Ponce de Leon Blvd, Coral Gables, Florida, 33146, USA.
Gregory A TalaveraDivision of Health Promotion and Behavioral Science, Graduate School of Public Health, San Diego State University, 9245 Sky Park Court, Suite 100 / HH 138, San Diego, CA, 92123-4311, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, 1819 West Polk Street Suite 246, Chicago, IL, 60612, USA.
Eliseo J Pérez-StableDivision of Intramural Research; National Heart, Lung, And Blood Institute; 3 Center Drive, Bethesda, MD, 20892-0311, USA.
National Heart Lung and Blood Institute · USSan Diego State University · USAlbert Einstein College of Medicine · USEmory University · USNational Institute on Aging · USUniversity of California, Irvine · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

backgroundThe Environmental Affordances Model (EAM) proposes that the effects of chronic stress on depression are moderated by unhealthy behaviors and race/ethnicity. The unique social structures and contexts of Hispanics/Latinos in the U.S. may influence such relationships. This study evaluated whether unhealthy behaviors weakened the relationship between allostatic load, a measure of chronic stress, and future elevated depressive symptoms among Hispanic Community Health Study/Study of Latinos participants.

methodsLongitudinal data (2008-2011 and 2014-2017) from 11,623 participants were analyzed. The exposure was allostatic load, an index of twelve established biomarkers categorized using clinically relevant cut points, at Visit 1. Elevated depressive symptoms were operationalized as a score of ≥10 (out of 30) on the CES-D 10 at Visit 2. An index of unhealthy behaviors, with one point each for cigarette smoking, excessive/binge drinking, sedentary behavior, and poor diet quality at Visit 1, was examined as an effect modifier. Multivariable logistic regression, in the overall sample and among Mexicans specifically and adjusted for demographic characteristics and elevated depressive symptoms at Visit 1, was used to model allostatic load, unhealthy behavior index (range: 0-4), and their interaction in relation to elevated depressive symptoms at Visit 2.

resultsOverall, greater allostatic load was associated with higher odds of elevated depressive symptoms after at least 6 years (aOR = 1.06, 95% CI = 1.01, 1.10). Overall, individuals with greater allostatic load and an unhealthy behavior index = 1, compared to those with an unhealthy behavior index = 0, had lower odds of elevated depressive symptoms at follow-up (aβ = -0.065, 95% CI = -0.12, -0.007).

conclusionsThe relationship between chronic stress and depression was partially moderated among Hispanics/Latinos who engaged in unhealthy behavior, which may have reduced their risk of elevated depressive symptoms given more chronic stress.

Indexed as

AllostasisDepressionHealth behaviorHispanic americansPhysiologicalStress

Identifiers

PMID34660875
PMCPMC8502772
OpenAlexW3198358278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.