Evidence map›Paper›PMID 34660865›Full record

ArticleArthroplasty today2021

Understanding the 30-day mortality burden after revision total knee arthroplasty.

SaTia T Sinclair, Melissa N Orr, Christopher A Rothfusz, Alison K Klika, John P McLaughlin, Nicolas S Piuzzi

2 registry-linked trialsAbstract read
In one paragraph

Article in Arthroplasty today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06525610 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Assessment of Bone Displacement Under Loading Following Periprosthetic Fracture Repair With Weight-Bearing CT

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2024 to 2025Enrolled21ConditionsPeriprosthetic Fracture Around Prosthetic Joint Implant KneeArmsPeriprosthetic Fracture Knee Repaired CT Scans
NCT06909916 narecruitingnot on this mapstarted 2024, after this paper: background citation

Assessment of Bone Displacement Under Loading Following Distal Femur Periprosthetic Fracture Repair With Weight-Bearing CT and Conventional CT

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2024 to 2025Enrolled20ConditionsPeriprosthetic Fracture Around Prosthetic Joint ImplantArmsPeriprosthetic Fracture Knee Repaired CT Scans
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

SaTia T SinclairDepartment of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Melissa N OrrDepartment of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Christopher A RothfuszDepartment of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Alison K KlikaDepartment of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
John P McLaughlinDepartment of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Nicolas S PiuzziDepartment of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn revision total knee arthroplasty (TKA), information regarding perioperative mortality risk is essential for careful decision-making. This study aimed to elucidate the (1) overall 30-day mortality rate and (2) 30-day mortality rate stratified by age, comorbidity, and septic vs aseptic failure after revision TKA.

methodsThe American College of Surgeons National Surgical Quality Improvement Program was reviewed for all patients undergoing revision TKA from 2011 to 2019. A total of 32,354 patients who underwent TKA were identified and categorized as mortality (n = 115) or mortality-free (n = 32,239). Patient characteristics were compared between cohorts and further stratified by septic and aseptic failure.

resultsThe overall 30-day mortality rate was 0.36%. The percentage of deaths per age group (normalized per 1000) was 0% (18-29 years), 0% (30-39 years), 0.18% (40-49 years), 0.13% (50-59 years), 0.14% (60-69 years), 0.40% (70-79 years), 1.25% (80-89 years), and 6.93% (90+ years). The percentage of deaths per American Society of Anesthesiologists (ASA) class was 0.30% (ASA 1), 0.06% (ASA 2), 0.39% (ASA 3), 2.41% (ASA 4), and 14.29% (ASA 5). Septic revision (

conclusionsIncreasing age, greater comorbidity burden, underweight or normal body mass index, insulin-dependent diabetes, septic revision, and general anesthesia were all associated with an increased risk of mortality after revision TKA. Notably, 1 in 80 patients aged 80-89 years died after revision TKA compared to 1 in 720 patients aged 60-69 years. Patients who underwent septic revision had a 4-fold increase in mortality compared to aseptic revision. Our stratified assessment of mortality provides a more individualized estimation of risk that can be used for patient counseling in revision TKA.

Indexed as

MortalityRevision total knee arthroplastyRisk assessmentTotal knee arthroplasty

Identifiers

PMID34660865
PMCPMC8502837

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.