ArticleFrontiers in cardiovascular medicine2021
Characterization of Flow Dynamics in the Pulmonary Bifurcation of Patients With Repaired Tetralogy of Fallot: A Computational Approach.
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Linking shape and clinical outcomes: Statistical shape model of Bidirectional Glenn connection in congenital single ventricle patients.PLOS digital health · 2026Article
- Pulmonary arterial flow alterations in systemic lupus erythematosus on 4D flow CMR: a case-control study.European radiology experimental · 2026Article
- Article
- Pulmonary Artery Shear Stress and Oscillatory Shear Index are Associated with Right Ventricular Remodeling in Repaired Tetralogy of Fallot.Annals of biomedical engineering · 2025Article
- Application feasibility of virtual models and computational fluid dynamics for the planning and evaluation of aortic repair surgery for Williams syndrome.Journal of cardiothoracic surgery · 2025Article
- Quantitative comparisons of pulmonary artery hemodynamics before and after Pulsta valve implantation in patients with Tetralogy of Fallot using computational fluid dynamics.Frontiers in cardiovascular medicine · 2025Article
- Cardiovascular magnetic resonance 4D flow derived aortic and pulmonary wall shear stress in pediatric patients with repaired tetralogy of Fallot.Frontiers in pediatrics · 2025Article
- Article
- Virtual Planning and Patient-Specific Graft Design for Aortic Repairs.Cardiovascular engineering and technology · 2024Article
- Reconstruction and Validation of Arterial Geometries for Computational Fluid Dynamics Using Multiple Temporal Frames of 4D Flow-MRI Magnitude Images.Cardiovascular engineering and technology · 2023Article
- A Comparison of Vessel Patch Materials in Tetralogy of Fallot Patients Using Virtual Surgery Techniques.Annals of biomedical engineering · 2023Article
- Calibration of patient-specific boundary conditions for coupled CFD models of the aorta derived from 4D Flow-MRI.Frontiers in bioengineering and biotechnology · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hemodynamic environment of the pulmonary bifurcation is of great importance for adult patients with repaired tetralogy of Fallot (rTOF) due to possible complications in the pulmonary valve and narrowing of the left pulmonary artery (LPA). The aim of this study was to computationally investigate the effect of geometrical variability and flow split on blood flow characteristics in the pulmonary trunk of patient-specific models. Data from a cohort of seven patients was used retrospectively and the pulmonary hemodynamics was investigated using averaged and MRI-derived patient-specific boundary conditions on the individualized models, as well as a statistical mean geometry. Geometrical analysis showed that curvature and tortuosity are higher in the LPA branch, compared to the right pulmonary artery (RPA), resulting in complex flow patterns in the LPA. The computational analysis also demonstrated high time-averaged wall shear stress (TAWSS) at the outer wall of the LPA and the wall of the RPA proximal to the junction. Similar TAWSS patterns were observed for averaged boundary conditions, except for a significantly modified flow split assigned at the outlets. Overall, this study enhances our understanding about the flow development in the pulmonary bifurcation of rTOF patients and associates some morphological characteristics with hemodynamic parameters, highlighting the importance of patient-specificity in the models. To confirm these findings, further studies are required with a bigger cohort of patients.
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