Evidence map›Paper›PMID 34660634›Full record

ArticleFrontiers in medicine2021

Gene Expression Analysis in Four Dogs With Canine Pemphigus Clinical Subtypes Reveals B Cell Signatures and Immune Activation Pathways Similar to Human Disease.

Haya S Raef, Cesar Piedra-Mora, Neil B Wong, Diana Junyue Ma, Clement N David, Nicholas A Robinson, Ramón M Almela, Jillian M Richmond

Abstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haya S RaefDepartment of Dermatology, UMass Medical School, Worcester, MA, United States.
Cesar Piedra-MoraClinical Sciences Department, Tufts Cummings School of Veterinary Medicine, Grafton, MA, United States.
Neil B WongDepartment of Dermatology, UMass Medical School, Worcester, MA, United States.
Diana Junyue MaDepartment of Dermatology, UMass Medical School, Worcester, MA, United States.
Clement N DavidNanoString Technologies Inc., Seattle, WA, United States.
Nicholas A RobinsonClinical Sciences Department, Tufts Cummings School of Veterinary Medicine, Grafton, MA, United States.
Ramón M AlmelaClinical Sciences Department, Tufts Cummings School of Veterinary Medicine, Grafton, MA, United States.
Jillian M RichmondDepartment of Dermatology, UMass Medical School, Worcester, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigus is a group of autoimmune-mediated mucocutaneous blistering diseases characterized by acantholysis. Pemphigus has also been recognized in dogs and shares similar clinical characteristics and variants with human pemphigus. While relationships between human and canine pemphigus have been reported, gene expression patterns across species have not been described in the literature. We sought to perform gene expression analysis of lesional skin tissue from four dogs with various forms of pemphigus to examine gene expression during spontaneous disease in dogs. We found increased T and B cell signatures in canine pemphigus lesions compared to controls, as well as significant upregulation of

Indexed as

autoimmune blistering diseasescanine (dog)comparative immunologycytokinegene expressionNanoStringpemphigusskin

Identifiers

PMID34660634
PMCPMC8511432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.