ReviewFrontiers in medicine2021
Plethysmographic Peripheral Perfusion Index: Could It Be a New Vital Sign?
Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06535581 (Perfusion Index in the Follow-up of Postoperative Pain; Hypertension Patient Sample), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perfusion Index in the Follow-up of Postoperative Pain; Hypertension Patient Sample
Who cites it
28 citing papers in PubMed.
- Trial
- Norepinephrine Dose and Pulse Oximetry Agreement During Critical Illness: A Prospective Repeated-Measures Study.Medicina (Kaunas, Lithuania) · 2026Article
- A New Proposed Approach to Categorize Sepsis Sub-phenotypes Based on Combined Trajectories of Perfusion Index and Central Venous Oxygen Saturation.Shock (Augusta, Ga.) · 2026Article
- Association between hemoglobin concentration and peripheral perfusion index in normovolemic patients: a prospective observational study.Journal of clinical monitoring and computing · 2026Article
- Article
- Peripheral perfusion noninvasive monitoring technologies - a literature and patent review.Journal of clinical monitoring and computing · 2026Review
- Peripheral Perfusion Index: Normative Values from Electronically Reported CCHD Screening.Pediatric cardiology · 2026Article
- Microcirculation Monitoring in Septic Shock: Focused Review.Medicina (Kaunas, Lithuania) · 2026Review
- Deep learning-integrated multilayer thermal gradient sensing platform for real-time blood flow monitoring.Science advances · 2026Article
- High-mobility group box 1 protein, histone H3 and histone H4 are not associated with peripheral hypoperfusion in sepsis: a retrospective cohort study.Einstein (Sao Paulo, Brazil) · 2026Article
- Impaired peripheral perfusion during anesthesia is associated with postoperative delirium in older patients undergoing minimally invasive colorectal surgery: a retrospective observational study.Frontiers in medicine · 2026Article
- Interpretable photoplethysmography-based machine-learning model for noninvasive assessment of systolic blood pressure.Frontiers in physiology · 2026Article
- The predictive value of perfusion indices in the triage and clinical management of carbon monoxide poisoning.Journal of clinical monitoring and computing · 2025Observational
- Article
- Beyond the trial data: why conservative oxygenation targets require nuanced implementation in pediatric critical care.Translational pediatrics · 2025Article
- Effect of contralateral limb exercise on peripheral perfusion index in a resting limb.The Indian journal of medical research · 2025Article
- Evaluation of intradialytic hypoxemia development in intensive care patients.BMC nephrology · 2025Observational
- Novel noninvasive prediction for pulse pressure variation: a machine learning-based model.British journal of anaesthesia · 2025Article
- The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: a safety study.medRxiv : the preprint server for health sciences · 2024Article
- Can peripheral perfusion index predict disease mortality in COVID-19 patients in the emergency department.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plethysmographic peripheral perfusion index (PPI) is a very useful parameter with various emerging utilities in medical practice. The PPI represents the ratio between pulsatile and non-pulsatile portions in peripheral circulation and is mainly affected by two main determinants: cardiac output and balance between sympathetic and parasympathetic nervous systems. The PPI decreases in cases of sympathetic predominance and/or low cardiac output states; therefore, it is a useful predictor of patient outcomes in critical care units. The PPI could be a surrogate for cardiac output in tests for fluid responsiveness, as an objective measure of pain especially in un-cooperative patients, and as a predictor of successful weaning from mechanical ventilation. The PPI is simple to measure, easy to interpret, and has continuously displayed variables, making it a convenient parameter for detecting the adequacy of blood flow and sympathetic-parasympathetic balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.