Evidence map›Paper›PMID 34660607›Full record

ReviewFrontiers in cell and developmental biology2021

Retinal Stem/Progenitor Cells Derived From Adult Müller Glia for the Treatment of Retinal Degeneration.

Lay Khoon Too, Matthew P Simunovic

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. PARP inhibition preserves cone photoreceptors in rd2 retina.Acta neuropathologica communications · 2025
    Article
  4. Retinal glia in myopia: current understanding and future directions.Frontiers in cell and developmental biology · 2024
    Review
  5. Article
  6. The Role of SOX Transcription Factors in Ageing and Age-Related Diseases.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Advances in the study of Müller glia reprogramming in mammals.Frontiers in cellular neuroscience · 2023
    Review
  9. Critical Examination of Müller Glia-DerivedFrontiers in cell and developmental biology · 2022
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lay Khoon TooSave Sight Institute, The University of Sydney, Sydney, NSW, Australia.
Matthew P SimunovicSave Sight Institute, The University of Sydney, Sydney, NSW, Australia.
Sydney Hospital · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past two decades, progress in our understanding of glial function has been revolutionary. Within the retina, a subset of glial cells termed the "Müller glia (MG)," have been demonstrated to play key roles in retinal homeostasis, structure and metabolism. Additionally, MG have also been shown to possess the regenerative capacity that varies across species. In teleost fish, MG respond to injury by reprogramming into stem-like cells capable of regenerating lost tissue. The expression of stem/progenitor cell markers has been demonstrated broadly in mammalian MG, including human MG, but their

Indexed as

Müller gliaregenerationreprogrammingretinal degenerationstem-cell therapy

Identifiers

PMID34660607
PMCPMC8511496
OpenAlexW3203522128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.