Evidence map›Paper›PMID 34660600›Full record

ArticleFrontiers in cell and developmental biology2021

Characterization of the Zebrafish Cell Landscape at Single-Cell Resolution.

Mengmeng Jiang, Yanyu Xiao, Weigao E, Lifeng Ma, Jingjing Wang, Haide Chen, Ce Gao, Yuan Liao, Qile Guo, Jinrong Peng and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 101 citations in OpenAlex.

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  18. Skeletal Muscle Aging: Lessons From Teleosts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Mengmeng JiangBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yanyu XiaoCenter for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Weigao ECenter for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Lifeng MaCenter for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Jingjing WangBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Haide ChenBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ce GaoCollege of Animal Sciences, Zhejiang University, Hangzhou, China.
Yuan LiaoCenter for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Qile GuoZJU-UOE Institute, Zhejiang University School of Medicine, Haining, China.
Jinrong PengCollege of Animal Sciences, Zhejiang University, Hangzhou, China.
Xiaoping HanBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Guoji GuoBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNZhejiang Chinese Medical University · CNZhejiang University-University of Edinburgh Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zebrafish have been found to be a premier model organism in biological and regeneration research. However, the comprehensive cell compositions and molecular dynamics during tissue regeneration in zebrafish remain poorly understood. Here, we utilized Microwell-seq to analyze more than 250,000 single cells covering major zebrafish cell types and constructed a systematic zebrafish cell landscape. We revealed single-cell compositions for 18 zebrafish tissue types covering both embryo and adult stages. Single-cell mapping of caudal fin regeneration revealed a unique characteristic of blastema population and key genetic regulation involved in zebrafish tissue repair. Overall, our single-cell datasets demonstrate the utility of zebrafish cell landscape resources in various fields of biological research.

Indexed as

cross-species analysisregenerationsequencingsingle cellzebrafish

Identifiers

PMID34660600
PMCPMC8517238
OpenAlexW3201722103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.