ReviewFrontiers in bioengineering and biotechnology2021
Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects.
Review in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 81 citations in OpenAlex.
- Coinoculation of Pantoea phytobeneficialis PF55 and Trichoderma harzianum ESALQ 1306 enhances soil microbial activity and agronomic performance in onion.Archives of microbiology · 2026Article
- Effects of Sequential Fermentation withFoods (Basel, Switzerland) · 2026Article
- Metabolic Signatures of Breast Cancer Subtypes and the Metabolic Impact of Chemotherapy.Metabolites · 2026Article
- Optimization and scale up of L-malic acid production from methanol by the methylotrophic yeast Ogataea polymorpha.FEMS yeast research · 2026Article
- Redox engineering of thermophilic fungusMycology · 2026Article
- Unravelling Egyptian blue Lily (Nymphaea nouchali) organs' metabolome via UHPLC/PDA/ESI-QTOF-MS and in relation to their antioxidant and anti-cholinesterase effects.Scientific reports · 2025Article
- Effective energy harvesting of Yak by regulating the glucose and lipid metabolism in liver to adapt to the plateau environment.Scientific reports · 2025Article
- Antimicrobial, Antioxidant, Antitumor, and Anti-Inflammatory Properties ofAntioxidants (Basel, Switzerland) · 2025Article
- Metabolic fingerprinting to elucidate the biodegradation of phosphonoacetic acid and its impact on Penicillium metabolism.Biodegradation · 2025Article
- Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization.Microbial cell factories · 2025Article
- Morphological and metabolic changes in Changshan Huyou (Citrus changshan-huyou) following natural tetraploidization.BMC plant biology · 2025Article
- Glycerol bioconversion to biofuel and value-added products by yeasts.FEMS yeast research · 2025Review
- Pilot investigation of the rhizosphere microbial communities and metabolism of two cultivars ofFrontiers in microbiology · 2025Article
- Advancements in metabolic engineering: unlocking the potential of key organic acids for sustainable industrial applications.Frontiers in bioengineering and biotechnology · 2025Review
- Coprinolide, a novel antifungal tricyclic polyketide with a rare furanone-fused chromene skeleton isolated from the mushroomJournal of pesticide science · 2024Article
- Spectroscopic Studies of Lanthanide(III) Complexes with L-Malic Acid in Binary Systems.International journal of molecular sciences · 2024Article
- Phosphate limitation enhances malic acid production on nitrogen-rich molasses with Ustilago trichophora.Biotechnology for biofuels and bioproducts · 2024Article
- The forced activation of asexual conidiation inSynthetic and systems biotechnology · 2024Article
- Conditional expression of FumA inApplied and environmental microbiology · 2024Article
- Nanopore analysis of cis-diols in fruits.Nature communications · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malic acid, a four-carbon dicarboxylic acid, is widely used in the food, chemical and medical industries. As an intermediate of the TCA cycle, malic acid is one of the most promising building block chemicals that can be produced from renewable sources. To date, chemical synthesis or enzymatic conversion of petrochemical feedstocks are still the dominant mode for malic acid production. However, with increasing concerns surrounding environmental issues in recent years, microbial fermentation for the production of L-malic acid was extensively explored as an eco-friendly production process. The rapid development of genetic engineering has resulted in some promising strains suitable for large-scale bio-based production of malic acid. This review offers a comprehensive overview of the most recent developments, including a spectrum of wild-type, mutant, laboratory-evolved and metabolically engineered microorganisms for malic acid production. The technological progress in the fermentative production of malic acid is presented. Metabolic engineering strategies for malic acid production in various microorganisms are particularly reviewed. Biosynthetic pathways, transport of malic acid, elimination of byproducts and enhancement of metabolic fluxes are discussed and compared as strategies for improving malic acid production, thus providing insights into the current state of malic acid production, as well as further research directions for more efficient and economical microbial malic acid production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.