Evidence map›Paper›PMID 34660531›Full record

ArticleFrontiers in chemistry2021

Ultrashort Peptides and Gold Nanoparticles: Influence of Constrained Amino Acids on Colloidal Stability.

Silvia Locarno, Raffaella Bucci, Elisa Impresari, Maria Luisa Gelmi, Sara Pellegrino, Francesca Clerici

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Silvia LocarnoDipartimento di Fisica "Aldo Pontremoli", Università degli Studi di Milano, Milano, Italy.
Raffaella BucciDISFARM-Dipartimento di Scienze Farmaceutiche, Sezione Chimica Generale e Organica ''A. Marchesini", Università degli Studi di Milano, Milano, Italy.
Elisa ImpresariDISFARM-Dipartimento di Scienze Farmaceutiche, Sezione Chimica Generale e Organica ''A. Marchesini", Università degli Studi di Milano, Milano, Italy.
Maria Luisa GelmiDISFARM-Dipartimento di Scienze Farmaceutiche, Sezione Chimica Generale e Organica ''A. Marchesini", Università degli Studi di Milano, Milano, Italy.
Sara PellegrinoDISFARM-Dipartimento di Scienze Farmaceutiche, Sezione Chimica Generale e Organica ''A. Marchesini", Università degli Studi di Milano, Milano, Italy.
Francesca ClericiDISFARM-Dipartimento di Scienze Farmaceutiche, Sezione Chimica Generale e Organica ''A. Marchesini", Università degli Studi di Milano, Milano, Italy.
University of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poor colloidal stability of gold nanoparticles (AuNPs) in physiological environments remains one of the major limitations that contribute to their difficult translation from bench to clinic. For this reason, an active research field is the development of molecules able to hamper AuNPs aggregation tendency in physiological environments. In this context, synthetic peptides are gaining an increased interest as an alternative to the use of biomacromolecules and polymers, due to their easiness of synthesis and their profitable pharmacokinetic profile. In this work, we reported on the use of ultrashort peptides containing conformationally constrained amino acids (AAs) for the stabilization of AuNPs. A small library of non-natural self-assembled oligopeptides were synthesized and used to functionalize spherical AuNPs of 20 nm diameter,

Indexed as

biotinconstrained amino acidsgold nanoparticleself-assemblyultrashort peptides

Identifiers

PMID34660531
PMCPMC8517408
OpenAlexW3204158205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.