ReviewFrontiers in cellular and infection microbiology2021
Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions.
Review in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Characteristics of the Health-Associated Oral Microbiome in Young Nonhuman Primates.Molecular oral microbiology · 2026Article
- Oral Health Across the Menopausal Transition: Biological Pathways, Clinical Implications, and Future Perspectives.Journal of clinical medicine · 2026Review
- The Gut-Reproduction-Oral-Immune Axis: Microbial Dysbiosis as a Shared Driver in Polycystic Ovary Syndrome and Endometriosis.Current microbiology · 2026Review
- Dietary Nitrate Intake and 16S rRNA-Inferred Nitrite-Generating Capacity of the Subgingival Microbiome May Influence Glucose Metabolism: Results From the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS).Journal of clinical periodontology · 2026Article
- Association between oral microbial shifts and polycystic ovary syndrome: a systematic review.Journal of oral microbiology · 2026Review
- Effects of Initial Periodontal Therapy on Intraoral Bacterial Flora in Patients With Oral Contraceptive-Related Severe Gingivitis.Case reports in dentistry · 2026Article
- Shifting hormones, shaping health: Gender-affirming therapy & oral care.International journal of transgender health · 2026Article
- Oral-heart axis from pregnancy and postpartum: maternal oral microbiota relates with cardiac reverse remodeling.Journal of oral microbiology · 2026Article
- Review
- Review
- Androgens as the "old age stick" in skeletal muscle.Cell communication and signaling : CCS · 2025Review
- Acquisition of the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Salivary microbiome and MRP-8/14 levels in children with gingivitis, healthy children, and their mothers.Journal of periodontology · 2024Article
- Association between Salivary Hormones, Dental Caries, and Cariogenic Microorganisms during Pregnancy.Journal of clinical medicine · 2024Article
- Review
- Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know.Dentistry journal · 2024Review
- The oral microbiome of children in health and disease-a literature review.Frontiers in oral health · 2024Review
- Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans.Frontiers in endocrinology · 2024Review
- Temporal changes in ewe vaginal microbiota throughout gestation.Frontiers in microbiology · 2024Article
- The effect of sex steroid hormones on the ecology ofBiofilm · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex steroid hormones (SSH) are cholesterol-derived molecules. They are secreted into saliva and enter the oral cavity, triggering physiological responses from oral tissues, with possible clinical implications, such as gingival inflammation and bleeding. SSH and hormonal changes affect not only oral host cells but also oral microorganisms. Historically, most research has focused on the effect of hormonal changes on specific bacteria and yeasts. Recently a broader effect of SSH on oral microorganisms was suggested. In order to assess the role of SSH in host-microbe interactions in the oral cavity, this review focuses on how and up to what extent SSH can influence the composition and behavior of the oral microbiome. The available literature was reviewed and a comprehensive hypothesis about the role of SSH in host-microbiome interactions is presented. The limited research available indicates that SSH may influence the balance between the host and its microbes in the oral cavity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.