Evidence map›Paper›PMID 34660253›Full record

ArticleFrontiers in oncology2021

Pioneering

Lwando Mampunye, Nerina C van der Merwe, Kathleen A Grant, Armand V Peeters, Rispah Torrorey-Sawe, David J French, Kelebogile E Moremi, Martin Kidd, Petrus C van Eeden, Fredrieka M Pienaar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Review
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  8. Review
  9. Prevalence of Clinically Relevant GermlineFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lwando MampunyeDivision of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Nerina C van der MerweDivision of Human Genetics, National Health Laboratory Service, Universitas Hospital, Bloemfontein, South Africa.
Kathleen A GrantDepartment of Biomedical Sciences, Faculty of Health and Wellness, Cape Peninsula University of Technology, Cape Town, South Africa.
Armand V PeetersDivision of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Rispah Torrorey-SaweDivision of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
David J FrenchDivision of Health Science and Innovation, LGC Limited, Teddington, United Kingdom.
Kelebogile E MoremiDivision of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Martin KiddCentre for Statistical Consultation, University of Stellenbosch, Stellenbosch, South Africa.
Petrus C van EedenOncology Practice, Durbanville Mediclinic, Cape Town, South Africa.
Fredrieka M PienaarCancerCare, Panorama Mediclinic, Cape Town, South Africa.
Maritha J KotzeDivision of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stellenbosch University · ZACape Peninsula University of Technology · ZANational Health Laboratory Service · ZAMoi University · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research performed in South African (SA) breast, ovarian and prostate cancer patients resulted in the development of a rapid BRCA point-of-care (POC) assay designed as a time- and cost-effective alternative to laboratory-based technologies currently used for first-tier germline DNA testing. In this study the performance of the new assay was evaluated for use on a portable screening device (ParaDNA), with the long-term goal to enable rollout at POC as an inventive step to meet the World Health Organization's sustainable development goals for Africa. DNA samples for germline testing were obtained retrospectively from 50 patients with early-stage hormone receptor-positive breast cancer referred for genomic tumor profiling (MammaPrint). Currently, SA patients with the luminal-type breast cancer are not routinely selected for

Indexed as

AfricaBRCA1BRCA2breast cancerfirst-tier genetic testingpathologypharmacogenomicspoint-of-care

Identifiers

PMID34660253
PMCPMC8513538
OpenAlexW3203300015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.