Evidence map›Paper›PMID 34659996›Full record

ArticleCureus2021

Feasibility of Contrasting Brain Connectivity Patterns in Cognitive and Motor Cerebral Networks to Clinical Outcomes in Patients Surviving Acute Respiratory Failure: A Pilot Study.

Nathan Morelli, Nathan F Johnson, Evan P Cassity, Anna G Kalema, Peter E Morris, Ashley A Montgomery-Yates, Kirby P Mayer

Abstract read
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathan MorelliDepartment of Physical Therapy, High Point University, High Point, USA.
Nathan F JohnsonDepartment of Physical Therapy, University of Kentucky, Lexington, USA.
Evan P CassityDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky College of Medicine, Lexington, USA.
Anna G KalemaDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky College of Medicine, Lexington, USA.
Peter E MorrisDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky College of Medicine, Lexington, USA.
Ashley A Montgomery-YatesDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky College of Medicine, Lexington, USA.
Kirby P MayerDepartment of Physical Therapy, University of Kentucky, Lexington, USA.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Essential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research ScannerS10OD023573 · OD · UNIVERSITY OF KENTUCKY · PI SMITH, CHARLES DENNIS · 2017 to 2017
$813k
NCATS NIH HHS UL1 TR001998NIH HHS S10 OD023573
6 · The paper itself

Abstract

backgroundThere is a paucity of research regarding the feasibility and association of cerebral cortex function to patient outcomes after acute respiratory failure (ARF). PURPOSE: To determine the feasibility of functional connectivity measures and examine the association of functional connectivity to a multifaceted battery of outcomes in survivors of ARF.

methodsEight ARF patients (age:58±3.7, ICU days:10.4±8.6) completed functional magnetic resonance imaging (fMRI), cognitive, physical-function, anxiety, depression, and driving simulator tests at one month post-hospital discharge. Pearson's correlations assessed the relationship between functional connectivity within the default mode network (FPN), sensorimotor network (SMN), and frontoparietal network (FPN) to outcomes.

resultsLow physical-function (r=0.75, p=0.03) and divided-attention (r=-0.86, p=0.03) during the driving simulator task correlated with low FPN connectivity. Low SMN connectivity demonstrated relationships to slower gait speed (r=0.82, p=0.01) and low short physical performance battery (SPPB) scores (r=0.81, p=0.01).

conclusionsfMRI is feasible to assess ARF patients' post-ICU limitations, as low post-ARF brain connectivity may be linked to low physical function, providing potential development of therapeutic interventions.

Indexed as

cognitionmobilitymultifaceted outcomesneuroimaging biomarkerspost-icu brain connectivity

Identifiers

PMID34659996
PMCPMC8495532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.