Evidence map›Paper›PMID 34659885›Full record

ArticleAmerican journal of cancer research2021

Cyy260, a novel small molecule inhibitor, suppresses non-small cell lung cancer cell growth via JAK2/STAT3 pathway.

Yan Zhuang, Yue Ma, Sunshun Yan, Bing Zhao, Shuling Wu, Qianwen Zhang, Xiaoying Huang, Haiyang Zhao, Chengguang Zhao, Zhiguo Liu and 1 more

Abstract read
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan ZhuangThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Yue MaThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Sunshun YanThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University Wenzhou 325027, Zhejiang, China.
Bing ZhaoThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Shuling WuThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Qianwen ZhangSchool of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, Zhejiang, China.
Xiaoying HuangThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Haiyang ZhaoThe Institute of Life Sciences, Wenzhou University Wenzhou 325035, Zhejiang, China.
Chengguang ZhaoThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Zhiguo LiuThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Lehe YangThe First Affiliated Hospital, Wenzhou Medical University Wenzhou 325000, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is a malignant tumor that accounts for the most new cancer cases and cancer-related deaths worldwide, and the proliferation and metastasis of NSCLC are the main reasons for treatment failure and patient death. Traditional chemotherapeutic drugs have low selectivity, which can kill cancer cells and cause damage to normal cells at the same time. Therefore, it is particularly important to study therapies that target cancer cells and to find low-toxicity, high-efficiency anticancer drugs. Cyy260 is a novel small molecule inhibitor that we synthesized for the first time. Here, we investigated the

Indexed as

Cyy260inhibitorJAK2NSCLCSTAT3

Identifiers

PMID34659885
PMCPMC8493399

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.