Evidence map›Paper›PMID 34659828›Full record

ArticleJournal of obesity2021

Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort.

J Korduner, P M Nilsson, O Melander, M J Gerl, G Engström, E Bachus, M Magnusson, F Ottosson

Open access · goldAbstract read
In one paragraph

Article in Journal of obesity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Machine Learning in Nutrition Research.Advances in nutrition (Bethesda, Md.) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

J KordunerDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0003-4132-1516
P M NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0002-5652-8459
O MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0002-2581-484X
M J GerlLipotype GmbH, Dresden, Germany.ORCID 0000-0002-8074-7221
G EngströmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0002-8618-9152
E BachusDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0001-8665-6892
M MagnussonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0003-1710-5936
F OttossonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0002-8312-3545
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Method: Associations between different biomarkers (proteomics, lipidomics, and metabolomics) coupled to either MHO or metabolically unhealthy obese (MUO) individuals were analyzed through principal component analysis (PCA). Subjects were identified from a subsample of 416 obese individuals, selected from the Malmö Diet and Cancer study-Cardiovascular arm (MDCS-CV, Results: MHO individuals had a more metabolically favorable lipid and glucose profile than MUO subjects, that is, lower levels of traditional blood glucose and triglycerides, as well as a trend of lower metabolically unfavorable lipid biomarkers. PL2 (lipidomics, Conclusion: Compared to MUO individuals, corresponding MHO individuals present with a more favorable lipid metabolic profile, accompanied by a downregulation of potentially harmful proteomic biomarkers. This unique and extensive biomarker profiling presents novel data on potentially differentiating traits between these two obese phenotypes.

Indexed as

Metabolic SyndromeObesity, Metabolically BenignHumansMetabolomicsProteomicsRisk FactorsSweden

Identifiers

PMID34659828
PMCPMC8514926
OpenAlexW3204629563

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.