ArticleJournal of ophthalmology2021
Optic Nerve Head Hemoglobin Levels in Glaucoma: A Structural and Functional Correlation Study.
Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Combined diagnostic accuracy of two artificial intelligence systems for glaucoma diagnosis using color fundus photography.PloS one · 2026Article
- Correlation of optic nerve hemoglobin levels with structural and functional parameters in glaucoma.Scientific reports · 2025Article
- Estimation of normal and glaucomatous optic nerve morphology from perfusion.BMJ open ophthalmology · 2025Article
- Structural and vascular assessment of the optic nerve head and macula in chronic Chagas disease.Scientific reports · 2025Article
- High-density perimetry in the assessment of foveal avascular zone and macular structure in glaucoma.PloS one · 2025Article
- Automated Optic Nerve Head Hemoglobin Measurements versus General Ophthalmologists Evaluation to Differentiate Glaucomatous from Large Physiological Cupping: A Diagnostic Performance Comparative Study.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis.Journal of clinical medicine · 2023Article
- Agreement between Five Experts and the Laguna ONhE Automatic Colourimetric Application Interpreting the Glaucomatous Aspect of the Optic Nerve.Journal of clinical medicine · 2023Article
- Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate structural and functional correlations in glaucoma patients using optic nerve head hemoglobin (ONH Hb) measurements as determined by automated colorimetric analysis of conventional retinography.
methodsWe prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (standard automated perimetry, SAP), color fundus imaging (mydriatic retinography), and peripapillary retinal nerve fiber layer (pRNFL) assessment through spectral-domain optical coherence tomography (SD-OCT). Software Laguna ONhE was used to estimate the amount of ONH Hb and to determine the glaucoma discriminant function (GDF) index. Scatter plots were constructed, and regression analysis was used to investigate the correlations between GDF, average pRNFL thickness, and VF mean deviation (VFMD) index values. A secondary analysis was performed to compare each parameter between three different glaucoma groups divided according to VFMD values (mild, >-6 dB; moderate, -6 to -12 dB; and advanced, <-12 dB).
resultsOne hundred ninety-six eyes from 123 participants (69 with glaucoma and 54 controls) were enrolled. Overall, all parameters evaluated differed significantly between glaucomatous and control eyes (
conclusionOur results showed significant associations between ONH Hb values and both structural and functional damage in glaucoma obtained by SD-OCT and SAP, respectively. The nonlinear correlation we found and the GDF behavior along different disease stages suggest that ONH Hb levels' reduction may precede visual function changes in early glaucoma stages.
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Registered trials
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