Evidence map›Paper›PMID 34659794›Full record

ArticleBJPsych open2021

Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.

Urs Heilbronner, Fabian Streit, Thomas Vogl, Fanny Senner, Sabrina K Schaupp, Daniela Reich-Erkelenz, Sergi Papiol, Mojtaba Oraki Kohshour, Farahnaz Klöhn-Saghatolislam, Janos L Kalman and 41 more

Open access · goldAbstract read
In one paragraph

Article in BJPsych open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors at 20 institutions in 6 countries.

Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Thomas VoglInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
Sabrina K SchauppInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
Mojtaba Oraki KohshourInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran.
Farahnaz Klöhn-SaghatolislamInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0003-0930-4214
Maria HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Katrin GadeDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.ORCID https://orcid.org/0000-0001-8629-0579
Ashley L ComesInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
Till F M AndlauerDepartment of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany.ORCID https://orcid.org/0000-0002-2917-5889
Heike Anderson-SchmidtDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-7501-9556
Til StürmerDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Adrian LoerbroksInstitute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany.
Manfred AmelangDepartment of Psychology, University of Heidelberg, Germany.
Eric PoiselDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Jerome FooDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany; and Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany; and Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Germany.
Jörg ZimmermannPsychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.
Martin von HagenClinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Germany.
Carsten SpitzerDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Germany.
Max SchmaussDepartment of Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Germany.
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria.
Jens ReimerDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany.
Carsten KonradDepartment of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Germany.
Georg JuckelDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany.ORCID https://orcid.org/0000-0001-9860-9620
Fabian U LangDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Germany.
Markus JägerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Germany.
Christian FiggeKarl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Germany.
Andreas J FallgatterDepartment of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University Tübingen, Germany.
Detlef E DietrichAMEOS Clinical Center Hildesheim, Germany; and Center for Systems Neuroscience Hannover, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Germany.
Bernhardt T BauneDepartment of Psychiatry, University of Münster, Germany; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Australia; and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.
Volker AroltInstitute for Translational Psychiatry, University of Münster, Germany.
Ion-George AnghelescuDepartment of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Ole A AndreassenNORMENT Centre and KG Jebsen Centre for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Norway; and Division of Mental Health and Addiction, Oslo University Hospital, Norway.
Chi-Hua ChenDepartment of Radiology, University of California, USA.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA; and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany; and Institute of Virology, Technical University Munich/Helmholtz Zentrum München, Germany.ORCID https://orcid.org/0000-0003-3105-5672
Ludwig-Maximilians-Universität München · DEHeidelberg University · DEMünchen Klinik · DEUniversity of Bonn · DEUniversitätsmedizin Göttingen · DEUniversität Ulm · DEUniversity of Münster · DEAgaplesion Frankfurter Diakonie Kliniken · DEAhvaz Jundishapur University of Medical Sciences · IRHeinrich Heine University Düsseldorf · DEHelmholtz Zentrum München · DEJohns Hopkins University · USLWL-Universitätsklinikum Bochum · DEMedical University of Graz · ATOslo University Hospital · NOThe University of Melbourne · AUTUM Klinikum · DEUniversität Hamburg · DEUniversity of Augsburg · DEUniversity of Hildesheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus.

aimsWe examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection.

methodLinkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (

resultsWe observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (

conclusionsWe identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.

Indexed as

COVID-19extraversiongeneticspersonality traitssevere mental disorders

Identifiers

PMID34659794
PMCPMC8503053
OpenAlexW3204350247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.