Evidence map›Paper›PMID 34659703›Full record

ArticleChemical science2021

Coumarin luciferins and mutant luciferases for robust multi-component bioluminescence imaging.

Zi Yao, Donald R Caldwell, Anna C Love, Bethany Kolbaba-Kartchner, Jeremy H Mills, Martin J Schnermann, Jennifer A Prescher

Abstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools.Chembiochem : a European journal of chemical biology · 2023
    Article
  9. Review
  10. Red-Shifted Coumarin Luciferins for Improved Bioluminescence Imaging.Journal of the American Chemical Society · 2023
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zi YaoDepartment of Chemistry, University of California Irvine CA USA jpresche@uci.edu.
Donald R CaldwellChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick MD USA martin.schnermann@nih.gov.
Anna C LoveDepartment of Chemistry, University of California Irvine CA USA jpresche@uci.edu.
Bethany Kolbaba-KartchnerSchool of Molecular Sciences, Arizona State University Tempe AZ USA.
Jeremy H MillsSchool of Molecular Sciences, Arizona State University Tempe AZ USA.ORCID https://orcid.org/0000-0003-2017-1846
Martin J SchnermannChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick MD USA martin.schnermann@nih.gov.ORCID https://orcid.org/0000-0002-0503-0116
Jennifer A PrescherDepartment of Chemistry, University of California Irvine CA USA jpresche@uci.edu.ORCID https://orcid.org/0000-0002-9250-4702

Funding

purchase of an All-in-One Fluorescence MicroscopeR01GM107630 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PRESCHER, JENNIFER · 2013 to 2021
$2.6M
NIGMS NIH HHS R01 GM107630
6 · The paper itself

Abstract

Multi-component bioluminescence imaging requires an expanded collection of luciferase-luciferin pairs that emit far-red or near-infrared light. Toward this end, we prepared a new class of luciferins based on a red-shifted coumarin scaffold. These probes (CouLuc-1s) were accessed in a two-step sequence

Identifiers

PMID34659703
PMCPMC8442684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.