ArticleGastroenterology and hepatology from bed to bench2021
Introducing physical exercise as a potential strategy in liver cancer prevention and development.
Article in Gastroenterology and hepatology from bed to bench, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Exploring the role of adipokines in exercise-induced inhibition of tumor growth.Sports medicine and health science · 2025Article
- Effects of moderate intensity exercise on liver metabolism in mice based on multi-omics analysis.Scientific reports · 2024Article
- Network analysis of liver cancer: a system biology approach.Gastroenterology and hepatology from bed to bench · 2023Article
- EGR1 Is a Critical Gene in Response of Human Keratinocyte to Blue Light Radiation.Journal of lasers in medical sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to investigate the anticancer properties of physical activity by network analysis in trained rats.
backgroundMuch evidence supports the benefits of physical activity, most of which are related to metabolism regulation and body health. Deeper investigation deals with other features of physical activity, such as its anticancer properties.
methodsProtein-protein interaction network analysis was applied to investigate the proteome profile of livers of rats subjected to physical activity through bioinformatics. Twelve differentially expressed proteins were searched and analyzed by Cytoscape 3.7.2 and its plug-ins. The network was analyzed to identify hub-bottleneck nodes. An action map was constructed for the central proteins.
resultsAmong the queried proteins, Eno1 and Pgm1 were only assigned as hubs by Network Analzyer. Gpi, Pkm, Aldoa, and Aldoart2 were identified as central nodes among the first neighbors of network elements. Furthermore, the glycolytic, carbohydrate catabolic, and glucose metabolic processes are key elements that could be imperative in the mechanism of exercise in liver function. The anticancer properties of the central nodes were highlighted.
conclusionThe network findings indicate the anticancer properties of physical activity, which has also been supported by previous investigations.
Indexed as
Identifiers
34659659PMC8514208What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.