Evidence map›Paper›PMID 34659514›Full record

ArticleExperimental and therapeutic medicine2021

Ding's herbal enema treats dextran sulfate sodium-induced colitis in mice by regulating the gut microbiota and maintaining the Treg/Th17 cell balance.

Yan-Yan Tan, Yang Ding, Xueping Zheng, Gong-Jian Dai, Su-Min Zhang, Xu Yang, Da-Chao Xu, Peng Chen, Jia-Min Zhang, Jia-Ze Ma and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Yan-Yan TanDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Yang DingDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Xueping ZhengDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Gong-Jian DaiDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Su-Min ZhangDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Xu YangDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Da-Chao XuDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Peng ChenDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Jia-Min ZhangDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Jia-Ze MaDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Meng LiDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Shi-Cai HuangDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Yan LiuDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Yu-Ting ZhangDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Han XingDepartment of First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Kang DingDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Yi-Jiang DingDepartment of National Center of Colorectal Surgery, Jiangsu Integrate Colorectal Oncology Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ding's herbal enema (DHEP) is a traditional Chinese medicinal therapy that has been used to treat ulcerative colitis (UC) in China. The present study determined the molecular mechanism of the effect of DHEP in UC treatment. C57BL/6J mice were treated with 3.5% (w/v) dextran sulfate sodium (DSS) for 7 days to establish an animal model of colitis. The mice were divided into five groups (n=5): Control, vehicle, DHEP, mesalazine and β-sitosterol. After oral administration for 7 days, the body weight, disease activity index, histopathology and inflammatory factors were analyzed. The fractions of CD4

Indexed as

Ding's herbal enemagut microbiotashort-chain fatty acidsT cell differentiationulcerative colitisβ-sitosterol

Identifiers

PMID34659514
PMCPMC8515548
OpenAlexW3203805683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.