Evidence map›Paper›PMID 34659501›Full record

ReviewExperimental and therapeutic medicine2021

Non-alcoholic fatty liver disease and hematologic manifestations (Review).

Vlad Pădureanu, Dalia Dop, Alice Nicoleta Drăgoescu, Rodica Pădureanu, Anca Emanuela Mușetescu, Laurențiu Nedelcu

Open access · diamondAbstract readReview
In one paragraph

Review in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Vlad PădureanuDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Dalia DopDepartment of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Alice Nicoleta DrăgoescuDepartment of Anesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Rodica PădureanuDepartment of Internal Medicine, Emergency Clinical County Hospital of Craiova, 200642 Craiova, Romania.
Anca Emanuela MușetescuDepartment of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Laurențiu NedelcuDepartment of Internal Medicine, Faculty of Medicine, Transylvania University Brasov, 500019 Brașov, Romania.
University of Medicine and Pharmacy of Craiova · ROTransylvania University of Brașov · ROUniversity of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a multisystem disease, and it is associated with numerous extra-hepatic manifestations or additional co-occurring diseases. The aim of the present review was the identification and management of the hematologic manifestations of NAFLD. One of the triggers is considered to be iron abnormalities. Increased ferritin levels, hepatic iron deposits and iron overload are associated with NAFLD. The iron overload degree and severity are associated with the level of liver fibrosis and with the risk for hepatocellular carcinoma. Excess iron deposits refers to the dysmetabolic iron overload syndrome (DIOS) and it is characterized by steatosis associated with moderate tissue iron deposition and increased levels of serum ferritin, while the serum transferrin saturation was normal. Further prospective studies are necessary to determine whether NAFLD has an independent risk for hematologic symptoms, besides the known risk factors. Future studies are also needed in order to assess the increasing impact of NAFLD on the micro- and macro-vascular complications of this systemic disease.

Indexed as

ferritin levelsiron depositsnon-alcoholic fatty liversteatosis

Identifiers

PMID34659501
PMCPMC8515549
OpenAlexW3199992292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.