Evidence map›Paper›PMID 34659440›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Genome-Wide Regulation of Acupuncture and Moxibustion on Ulcerative Colitis Rats.

Zhaoqin Wang, Yan Huang, Di Wang, Rumeng Wang, Kunshan Li, Qin Qi, Zhe Ma, Muen Gu, Handan Zheng, Yuan Lu and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhaoqin WangDepartment of Aeronautics and Astronautics, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-3440-2230
Yan HuangShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-5588-0274
Di WangShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-8082-6544
Rumeng WangShanghai TCM-integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.ORCID https://orcid.org/0000-0002-8422-4452
Kunshan LiShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-0316-1753
Qin QiYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.ORCID https://orcid.org/0000-0002-0563-1560
Zhe MaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0003-0956-4438
Muen GuYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.ORCID https://orcid.org/0000-0001-6996-5044
Handan ZhengShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-8640-9194
Yuan LuShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.ORCID https://orcid.org/0000-0001-7584-5727
Luyi WuShanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID https://orcid.org/0000-0001-8888-1698
Shanghai University of Traditional Chinese Medicine · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture and moxibustion have definite clinical effects on treating ulcerative colitis (UC), but their mechanism is still unclear. To investigate the molecular mechanisms, we applied herb-partitioned moxibustion or electroacupuncture at the Tianshu (ST25) points on UC rats and used RNA sequencing to identify molecular consequences. Male Sprague Dawley (SD) rats were divided into 6 groups randomly: the normal control (NC) group, the control + herb-partitioned moxibustion (NCHM) group, the control + electroacupuncture (NCEA) group, the model (UC) group, the model + herb-partitioned moxibustion (UCHM) group, and the model + electroacupuncture (UCEA) group. Compared to the UC group, HE staining in the UCHM group and UCEA group indicated that colitis was relieved, the histopathological score and MPO were both significantly reduced, and the serum hs-CRP concentration was decreased significantly. The results of RNA-seq suggested that, compared to the NC group, 206 upregulated genes and 167 downregulated genes were identified in colon tissues from the UC group; compared to the UC group, the expression levels of some genes were both affected in the UCHM group and the UCEA group (684 differentially expressed genes were identified in the UCHM group, and 1182 differentially expressed genes were identified in the UCEA group). KEGG signal pathway analysis indicated that the differentially expressed genes in the UCHM group were associated with the JAK-STAT signaling pathway and cell adhesion molecule (CAM); the differentially expressed genes in the UCEA group were associated with the NF-

Identifiers

PMID34659440
PMCPMC8519700
OpenAlexW3202790685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.