ArticleEvidence-based complementary and alternative medicine : eCAM2021
Antiviral Effect of Hyunggaeyungyo-Tang on A549 Cells Infected with Human Coronavirus.
Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Proteomic analyses of seasonal human respiratory viruses unravel changes related to antiviral, inflammatory, and cell death pathways.iScience · 2026Article
- Article
- Antiviral Effect of Hyunggaeyungyo-Tang on A549 Cells Infected with Human Coronavirus.Evidence-based complementary and alternative medicine : eCAM · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerbal medicine is widely recommended to treat viral infectious diseases. Over 123,000,000 individuals have been infected with the coronavirus since a worldwide pandemic was declared in March 2020. We conducted this research to confirm the potential of herbal medicine as a treatment for coronavirus.
methodsWe infected the A549 cell line with betacoronavirus OC43 and then treated it with 100
resultsWe found that the effects of HYGYT decrease the expression level of pPKR, peIF2
conclusionThrough the reduction of the amount of coronavirus RNA, our research indicates that HGYGT has antiviral effects. The reduction of IKK and iNOS mRNA levels indicate that HGYGT reduces coronavirus RNA expression and may inhibit the replication of coronavirus by acting on NF-kB/Rel pathways to protect oxidative injury. In addition, decreases in mRNA expression levels of proinflammatory cytokines indicate that the HGYGT may relieve the symptoms of coronavirus infections.
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Registered trials
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