Evidence map›Paper›PMID 34659421›Full record

ArticleJournal of tropical medicine2021

Evaluation of

Nibedita Das, Sanowar Hossain, Jaytirmoy Barmon, Shahnaj Parvin, Mahadi Hasan, Masuma Akter, Ekramul Islam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. A flavone from the ethyl acetate extract ofBiochemistry and biophysics reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nibedita DasRajshahi Medical College, Rajshahi 6100, Bangladesh.
Sanowar HossainDepartment of Pharmacy, Pabna University of Science and Technology, Pabna 6600, Bangladesh.
Jaytirmoy BarmonDepartment of Pharmacy, Varendra University, Kazla, Rajshahi, Bangladesh.
Shahnaj ParvinDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
Mahadi HasanDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
Masuma AkterDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
Ekramul IslamDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID https://orcid.org/0000-0003-4664-3709
University of Rajshahi · BDPabna University of Science and Technology · BDRajshahi Medical College · BDVarendra University · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe leaves of

methodsThe protective activity of the ethyl acetate fraction (EAF) of the extract was investigated by evaluating the inhibition of oxidative damage of pUC19 plasmid DNA as well as hemolysis and lipid peroxidation damage to human erythrocytes induced by 2,2'-azobis-2-amidinopropane (AAPH). Antitumor activity was assessed by evaluating the percentage inhibition of cell growth, morphological changes of Ehrlich's ascites carcinoma (EAC) cells, and hematological parameters. Antimicrobial activity was determined by the disc diffusion method against different resistant microorganisms.

resultsEAF effectively inhibited AAPH-induced oxidative damage to DNA because it can inhibit the transformation of the supercoiled form of plasmid DNA to open circular and further linear form. The oxidative hemolysis caused by AAPH in human erythrocytes was inhibited by EAF extract in a time-dependent manner, and the production of malondialdehyde (MDA) was significantly reduced, which indicates the prevention of lipid peroxidation. In antitumor assay, 76% growth of inhibition of EAC was observed compared with the control mice (

conclusionEAF may have great importance in preventing oxidative damage to DNA, erythrocytes, and other cellular components as well as can be a good candidate in cancer chemotherapy and treating infectious diseases caused by antibiotic-resistant bacteria.

Identifiers

PMID34659421
PMCPMC8514968
OpenAlexW3204389577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.