Evidence map›Paper›PMID 34659412›Full record

ArticleJournal of oncology2021

Exosomes Derived from RM-1 Cells Promote the Recruitment of MDSCs into Tumor Microenvironment by Upregulating CXCR4 via TLR2/NF-

Nan Li, Yingying Wang, Haoyu Xu, Hexi Wang, Yingying Gao, Yao Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 17 citations in OpenAlex.

  1. Molecular Mechanisms and Immune Regulation in Prostate Cancer: A Review.International journal of molecular sciences · 2026
    Review
  2. Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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  20. Exosomes in cancer immunoediting and immunotherapy.Asian journal of pharmaceutical sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nan LiDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 402160, China.
Yingying WangDepartment of Oncology, People Hospital of Jiulongpo District, Chongqing 400050, China.
Haoyu XuDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 402160, China.
Hexi WangDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 402160, China.
Yingying GaoDepartment of Laboratory Diagnosis, People's Hospital of Banan District, Chongqing 401300, China.ORCID https://orcid.org/0000-0002-4730-9668
Yao ZhangDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 402160, China.ORCID https://orcid.org/0000-0001-8878-891X
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNChongqing Jiulongpo People's Hospital · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloid-derived suppressor cells (MDSCs) play a critical role in tumor immune escape because of its remarkable immunosuppressive effect. However, the mechanism of MDSCs migrated into tumor microenvironment remains unclear. In this study, we demonstrated the recruitment of MDSCs can be promoted by exosomes derived from prostate cancer cells, which could upregulate chemokine (CXC motif) receptor 4 (CXCR4) via the TLR2/NF-

Identifiers

PMID34659412
PMCPMC8519695
OpenAlexW3202886431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.