Evidence map›Paper›PMID 34659270›Full record

ArticleFrontiers in immunology2021

Macrophage Activation Syndrome and COVID 19: Impact of MAPK Driven Immune-Epigenetic Programming by SARS-Cov-2.

Roshan Kumar Roy, Uttam Sharma, Mishi Kaushal Wasson, Aklank Jain, Md Imtaiyaz Hassan, Hridayesh Prakash

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Mucosal implications of oral Jak3-targeted drugs in COVID patients.Molecular medicine (Cambridge, Mass.) · 2025
    Review
  4. Article
  5. Review
  6. Immunity and Coagulation in COVID-19.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
  11. Article
  12. COVID-19 and cellular senescence.Nature reviews. Immunology · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roshan Kumar RoyAmity Institute of Virology and Immunology, Amity University, NOIDA, Udham Singh Nagar, India.
Uttam SharmaDepartment of Zoology, Central University of Punjab, Bathinda, India.
Mishi Kaushal WassonAmity Institute of Virology and Immunology, Amity University, NOIDA, Udham Singh Nagar, India.
Aklank JainDepartment of Zoology, Central University of Punjab, Bathinda, India.
Md Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.
Hridayesh PrakashAmity Institute of Virology and Immunology, Amity University, NOIDA, Udham Singh Nagar, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Epigenesis, GeneticHumansImmunity, InnateLungMacrophage Activation SyndromeMacrophagesp38 Mitogen-Activated Protein KinasesRespiratory Distress SyndromeSARS-CoV-2p38 Mitogen-Activated Protein KinasesCOVID-19immune polarizationinflammasomelncRNAsmacrophageMAPKmiRNATLRs (toll-like receptors)

Identifiers

PMID34659270
PMCPMC8519338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.