Evidence map›Paper›PMID 34659241›Full record

ArticleFrontiers in immunology2021

Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated

Dimitra Lamprinaki, Pilar Garcia-Vello, Roberta Marchetti, Charlotte Hellmich, Kelli A McCord, Kristian M Bowles, Matthew S Macauley, Alba Silipo, Cristina De Castro, Paul R Crocker and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  5. JACS Au · 2026
    Article
  6. Review
  7. The role ofJournal of oral microbiology · 2026
    Review
  8. Review
  9. JACS Au · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Potential and application ofFrontiers in microbiology · 2025
    Article
  19. Impact ofFrontiers in immunology · 2025
    Article
  20. Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Dimitra LamprinakiQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Pilar Garcia-VelloDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Roberta MarchettiDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Charlotte HellmichNorfolk and Norwich University Hospitals, NHS Foundation Trust, Norwich, United Kingdom.
Kelli A McCordDepartments of Chemistry, and Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Kristian M BowlesNorfolk and Norwich University Hospitals, NHS Foundation Trust, Norwich, United Kingdom.
Matthew S MacauleyDepartments of Chemistry, and Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Alba SilipoDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Cristina De CastroDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Paul R CrockerDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Nathalie JugeQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
University of Naples Federico II · ITUniversity of Alberta · CANorfolk and Norwich University Hospitals NHS Foundation Trust · GBNorwich Research Park · GBQuadram Institute · GBUniversity of Dundee · GBUniversity of East Anglia · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M011216/1Biotechnology and Biological Sciences Research Council BB/R012490/1Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10353Wellcome TrustWellcome Trust 103744/Z/14/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antigens, Differentiation, MyelomonocyticCarcinogenesisCell LineColorectal NeoplasmsDendritic CellsFusobacteriumHumansImmunomodulationLectinsMacrophagesAntigens, Differentiation, MyelomonocyticLectinsSIGLEC7 protein, humancolorectal cancerFusobacterium nucleatuminnate immunitylipopolysaccharideouter membrane vesicleSiglec-7

Identifiers

PMID34659241
PMCPMC8517482
OpenAlexW3203464814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.