Evidence map›Paper›PMID 34659223›Full record

ArticleFrontiers in immunology2021

Semen-Derived Exosomes Mediate Immune Escape and Transmission of Reticuloendotheliosis Virus.

Qi Su, Yawen Zhang, Zhizhong Cui, Shuang Chang, Peng Zhao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Role of Seminal Exosomes in Reproduction.Journal of cellular physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qi SuCollege of Veterinary Medicine, Shandong Agricultural University, Tai'an City, China.
Yawen ZhangCollege of Veterinary Medicine, Shandong Agricultural University, Tai'an City, China.
Zhizhong CuiCollege of Veterinary Medicine, Shandong Agricultural University, Tai'an City, China.
Shuang ChangCollege of Veterinary Medicine, Shandong Agricultural University, Tai'an City, China.
Peng ZhaoCollege of Veterinary Medicine, Shandong Agricultural University, Tai'an City, China.
Shandong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reticuloendotheliosis virus (REV) causes immune-suppression disease in poultry, leading to a significant economic burden worldwide. Recent evidence demonstrated that the REV can enter the semen and then induce artificial insemination, but how the virus gets into semen was little known. Accumulating studies indicated that exosomes serve as vehicles for virus transmission, but the role of exosomes in viral shedding through the semen remains unclear. In this study, exosomes purified from the REV-positive semen were shown with reverse transcription-PCR and mass spectrometry to contain viral genomic RNA and viral proteins, which could also establish productive infections both

Indexed as

Immune EvasionInfectious Disease Transmission, VerticalVirus SheddingAnimalsAntibodies, NeutralizingAntibodies, ViralCells, CulturedChickensExosomesHost-Pathogen InteractionsImmunity, InnateMaleReticuloendotheliosis, AvianReticuloendotheliosis virusSemenViral LoadAntibodies, NeutralizingAntibodies, Viralcock semenexosomeimmune escapereticuloendotheliosis virustransmission

Identifiers

PMID34659223
PMCPMC8517439
OpenAlexW3203646524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.