Evidence map›Paper›PMID 34659205›Full record

ArticleFrontiers in immunology2021

Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model.

Niamh Fahy, Virginia Palomares Cabeza, Andrea Lolli, Janneke Witte-Bouma, Ana Merino, Yanto Ridwan, Eppo B Wolvius, Martin J Hoogduijn, Eric Farrell, Pieter A J Brama

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Regenerative capacity of human pluripotent stem cell-derived articular chondrocytes in vitro.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niamh FahyDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Virginia Palomares CabezaDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Andrea LolliDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Janneke Witte-BoumaDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Ana MerinoTransplantation Institute, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Yanto RidwanDepartment of Genetics, Erasmus Medical Center, Rotterdam, Netherlands.
Eppo B WolviusDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Martin J HoogduijnTransplantation Institute, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Eric FarrellDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Pieter A J BramaSchool of Veterinary Medicine, University College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue engineering approaches using progenitor cells such as mesenchymal stromal cells (MSCs) represent a promising strategy to regenerate bone. Previous work has demonstrated the potential of chondrogenically primed human MSCs to recapitulate the process of endochondral ossification and form mature bone

Indexed as

Calcification, PhysiologicCell DifferentiationChondrogenesisAnimalsBiomarkersBone RegenerationCells, CulturedHumansImmunityMesenchymal Stem CellsMiceModels, AnimalMonocytesTissue EngineeringT-Lymphocyte SubsetsX-Ray MicrotomographyBiomarkersadaptive immunityendochondral ossificationgraft rejectionimmunocompetenceinnate immunitymesenchymal stem cellsosteoimmunologyxenogeneic

Identifiers

PMID34659205
PMCPMC8515138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.