ArticleFrontiers in microbiology2021
Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Insights into the Mechanism Underlying the Symbiosis between Seagrass and a Lulworthiaceae Fungus.Microbial ecology · 2026Article
- Bioactive Secondary Metabolites at the Ends of the Earth (2015-2025): Insights into Arctic and Antarctic Aquatic Sources.Marine drugs · 2026Review
- Compartment-specific microbial communities highlight the ecological roles of fungi in a subtropical seagrass ecosystem.Applied and environmental microbiology · 2025Article
- Article
- Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review.Archives of pharmacal research · 2024Review
- Bioactive Naphtho-α-Pyranones from Two Endophytic Fungi of the GenusAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Marine Compounds for Melanoma Treatment and Prevention.International journal of molecular sciences · 2022Review
- Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus.Marine drugs · 2022Article
- Selective isolation of Arctic marine actinobacteria and a down-scaled fermentation and extraction strategy for identifying bioactive compounds.Frontiers in microbiology · 2022Article
- Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine MushroomMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of drug-resistant bacteria is increasing rapidly in all parts of the world, and the need for new antibiotics is urgent. In our continuous search for new antimicrobial molecules from under-investigated Arctic marine microorganisms, a marine fungus belonging to the family Lulworthiaceae (Lulworthiales, Sordariomycetes, and Ascomycota) was studied. The fungus was isolated from driftwood, cultivated in liquid medium, and studied for its potential for producing antibacterial compounds. Through bioactivity-guided isolation, a novel sulfated biarylic naphtho-α-pyrone dimer was isolated, and its structure was elucidated by spectroscopic methods, including 1D and 2D NMR and HRMS. The compound, named lulworthinone (
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