Evidence map›Paper›PMID 34659115›Full record

ArticleFrontiers in endocrinology2021

Restoration of mRNA Expression of Solute Carrier Proteins in Liver of Diet-Induced Obese Mice by Metformin.

Jiamei Le, Yi Fu, Qiuqin Han, Xindong Wei, Houlin Ji, Yifan Chen, Qiuying Wang, Peixian Pi, Jilei Li, Xinjie Lin and 3 more

Open access · goldFull text read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. ARHGDIB Modulates Subcutaneous Fat Deposition in Ducks.Animals : an open access journal from MDPI · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jiamei LeShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Yi FuShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Qiuqin HanShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Xindong WeiShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Houlin JiShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Yifan ChenShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Qiuying WangShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Peixian PiShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Jilei LiShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Xinjie LinShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Xiaoying ZhangMetabolic Disease Research Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Yong ZhangMetabolic Disease Research Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Jianping YeMetabolic Disease Research Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Shanghai University of Medicine and Health Sciences · CNZhengzhou Central Hospital · CNShanghai University of Traditional Chinese Medicine · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metformin (MET), the most common medicine for type 2 diabetes (T2DM), improves insulin sensitivity by targeting the liver, intestine and other organs. Its impact on expression of the solute carrier (

Indexed as

ObesityAnimalsDiet, High-FatGene Expression RegulationGlucoseGlucose Tolerance TestHepatocytesInsulin ResistanceLiverMaleMetforminMiceMice, Inbred C57BLMice, ObeseRNA, MessengerSolute Carrier ProteinsGlucoseMetforminRNA, MessengerSolute Carrier Proteinsinsulin sensitivitymetforminobesitysolute carrier transportertranscriptome

Identifiers

PMID34659115
PMCPMC8515182
OpenAlexW3204952272

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.