Evidence map›Paper›PMID 34658916›Full record

ArticleFrontiers in physiology2021

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle.

Joshua C Drake, Rebecca J Wilson, Di Cui, Yuntian Guan, Mondira Kundu, Mei Zhang, Zhen Yan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. T-lymphocytes suppression by CD14Journal of translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joshua C DrakeDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States.
Rebecca J WilsonDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, United States.
Di CuiCenter for Skeletal Muscle Research, The Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States.
Yuntian GuanCenter for Skeletal Muscle Research, The Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States.
Mondira KunduDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Mei ZhangDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States.
Zhen YanDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States.
University of Virginia · USSt. Jude Children's Research Hospital · US

Funding

p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
mitoAMPK in exercise benefitsR01AR077440 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2020 to 2024
$2.1M
NIAMS NIH HHS R01 AR050429NIAMS NIH HHS R01 AR077440
6 · The paper itself

Abstract

Unc51 like autophagy activating kinase 1 (Ulk1), the primary autophagy regulator, has been linked to metabolic adaptation in skeletal muscle to exercise training. Here we compared the roles of Ulk1 and homologous Ulk2 in skeletal muscle insulin action following exercise training to gain more mechanistic insights. Inducible, skeletal muscle-specific

Indexed as

autophagyexerciseinsulin signalingskeletal muscleUnc51 like autophagy activating kinase

Identifiers

PMID34658916
PMCPMC8514673
OpenAlexW3202755793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.