Evidence map›Paper›PMID 34658862›Full record

ArticleFrontiers in pharmacology2021

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone.

Wang Yajun, Cui Jin, Gu Zhengrong, Fang Chao, Hu Yan, Weng Weizong, Li Xiaoqun, Zhou Qirong, Chen Huiwen, Zhang Hao and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Wang YajunGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Cui JinDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Gu ZhengrongDepartment of Orthopedics, Luodian Hospital, Shanghai, China.
Fang ChaoGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Hu YanDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Weng WeizongDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Li XiaoqunDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Zhou QirongDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Chen HuiwenGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Zhang HaoGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Guo JiaweiGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Zhuang XinchenGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Sheng ShihaoGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Wang SichengInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Chen XiaoDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Su JiacanDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Second Military Medical University · CNChanghai Hospital · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated and function as "osteo-chondral unit" in the joint. Abnormal mechanical load leads to activated osteoclast activity and increased bone resorption in the subchondral bone, which is implicated in the onset of OA pathogenesis. Thus, inhibiting subchondral bone osteoclast activation could prevent OA onset. Betaine, isolated from the Lycii Radicis Cortex (LRC), has been demonstrated to exert anti-inflammatory, antifibrotic and antiangiogenic properties. Here, we evaluated the effects of betaine on anterior cruciate ligament transection (ACLT)-induced OA mice. We observed that betaine decreased the number of matrix metalloproteinase 13 (MMP-13)-positive and collagen X (Col X)-positive cells, prevented articular cartilage proteoglycan loss and lowered the OARSI score. Betaine decreased the thickness of calcified cartilage and increased the expression level of lubricin. Moreover, betaine normalized uncoupled subchondral bone remodeling as defined by lowered trabecular pattern factor (Tb.pf) and increased subchondral bone plate thickness (SBP). Additionally, aberrant angiogenesis in subchondral bone was blunted by betaine treatment. Mechanistically, we demonstrated that betaine suppressed osteoclastogenesis

Indexed as

angiogenesisbetaineosteoarthritisosteoclastogenesissubchondral bone

Identifiers

PMID34658862
PMCPMC8511433
OpenAlexW3203241425

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.