Evidence map›Paper›PMID 34658838›Full record

ArticleFrontiers in aging neuroscience2021

Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease.

Manish D Paranjpe, Stella Belonwu, Jason K Wang, Tomiko Oskotsky, Aarzu Gupta, Alice Taubes, Kelly A Zalocusky, Ishan Paranjpe, Benjamin S Glicksberg, Yadong Huang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Meta-Analysis of Transcriptomic Studies of Blood and Six Brain Regions Identifies a Consensus of 15 Cross-Tissue Mechanisms in Alzheimer's Disease and Suggests an Origin of Cross-Study Heterogeneity.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  11. Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  15. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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  18. medRxiv : the preprint server for health sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Manish D ParanjpeBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Stella BelonwuBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Jason K WangHarvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Boston, MA, United States.
Tomiko OskotskyBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Aarzu GuptaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Alice TaubesBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Kelly A ZalocuskyThe Gladstone Institute of Neurological Disease, San Francisco, CA, United States.
Ishan ParanjpeBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Benjamin S GlicksbergHasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Yadong HuangThe Gladstone Institute of Neurological Disease, San Francisco, CA, United States.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USGladstone Institutes · USHarvard University · USIcahn School of Medicine at Mount Sinai · US

Funding

ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's DiseaseR01AG057683 · NIA · J. DAVID GLADSTONE INSTITUTES · PI HUANG, YADONG, SIROTA, MARINA · 2017 to 2021
$4.3M
An Integrative Multi-Omics Approach to Elucidate Sex-Specific Differences in Alzheimers DiseaseR01AG060393 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIROTA, MARINA · 2018 to 2022
$4.1M
NIA NIH HHS R01 AG057683NIA NIH HHS R01 AG060393
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s diseaseAPOEbiomarkerinflammationneuroinflammationsextranscriptomics

Identifiers

PMID34658838
PMCPMC8515049
OpenAlexW3203119495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.