ArticleFrontiers in integrative neuroscience2021
Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder.
Article in Frontiers in integrative neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022Pooled it
- When hearing loss mimics autism: Enlarged vestibular aqueduct syndrome in an 11-year-old child-A case report.The Journal of international medical research · 2026Article
- Autism associatedbioRxiv : the preprint server for biology · 2026Article
- Directionally biased neuronal responses to pitch-axis vestibular stimulation in larval zebrafish compared to roll-axis responses.Communications biology · 2026Article
- Sensory Processing of Time and Space in Autistic Children.Children (Basel, Switzerland) · 2025Article
- Auditory Brainstem Response Findings in Children with Level 1 Autism Spectrum Disorder: A Comparative Study.International archives of otorhinolaryngology · 2025Article
- Editorial: Cellular and synaptic mechanisms in the auditory system in health and disease.Frontiers in cellular neuroscience · 2025Article
- Phybrata Digital Biomarkers of Age-Related Balance Impairments, Sensory Reweighting, and Intrinsic Fall Risk.Medical devices (Auckland, N.Z.) · 2025Article
- Haptic and visuo-haptic impairments for object recognition in children with autism spectrum disorder: focus on the sensory and multisensory processing dysfunctions.Experimental brain research · 2024Article
- Cortical dysmorphology and reduced cortico-collicular projections in an animal model of autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.Neuron · 2024Article
- Incidence of Otolaryngological Manifestations in Individuals with Autism Spectrum Disorder: A Special Focus on Auditory Disorders.Audiology research · 2024Review
- Obliteration of a glycinergic projection to the medial geniculate in an animal model of autism.Frontiers in cellular neuroscience · 2024Article
- A cross-sectional study on the neurocognitive outcomes in vestibular impaired school-aged children: are they at higher risk for cognitive deficits?Journal of neurology · 2023Article
- Impaired cerebellar plasticity hypersensitizes sensory reflexes inbioRxiv : the preprint server for biology · 2023Article
- Effects of sensory integration training on balance function and executive function in children with autism spectrum disorder: evidence from Footscan and fNIRS.Frontiers in psychology · 2023Article
- Sensitivity to interaural level and time differences in individuals with autism spectrum disorder.Scientific reports · 2022Article
- Sensory Profiles in School-Aged Children with Autism Spectrum Disorder: A Descriptive Study Using the Sensory Processing Measure-2 (SPM-2).Journal of clinical medicine · 2022Article
- Balance and Vestibular Deficits in Pediatric Patients with Autism Spectrum Disorder: An Underappreciated Clinical Aspect.Autism research and treatment · 2022Article
- Detecting Time Concept Competence in Children with Autism Spectrum and Attention Disorders.Neuropsychiatric disease and treatment · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, poor social skills, and difficulties with communication. Beyond these core signs and symptoms, the majority of subjects with ASD have some degree of auditory and vestibular dysfunction. Dysfunction in these sensory modalities is significant as normal cognitive development depends on an accurate representation of our environment. The hearing difficulties in ASD range from deafness to hypersensitivity and subjects with ASD have abnormal sound-evoked brainstem reflexes and brainstem auditory evoked potentials. Vestibular dysfunction in ASD includes postural instability, gait dysfunction, and impaired gaze. Untreated vestibular dysfunction in children can lead to delayed milestones such as sitting and walking and poor motor coordination later in life. Histopathological studies have revealed that subjects with ASD have significantly fewer neurons in the auditory hindbrain and surviving neurons are smaller and dysmorphic. These findings are consistent with auditory dysfunction. Further, the cerebellum was one of the first brain structures implicated in ASD and studies have revealed loss of Purkinje cells and the presence of ectopic neurons. Together, these studies suggest that normal auditory and vestibular function play major roles in the development of language and social abilities, and dysfunction in these systems may contribute to the core symptoms of ASD. Further, auditory and vestibular dysfunction in children may be overlooked or attributed to other neurodevelopmental disorders. Herein we review the literature on auditory and vestibular dysfunction in ASD. Based on these results we developed a brainstem model of central auditory and vestibular dysfunction in ASD and propose that simple, non-invasive but quantitative testing of hearing and vestibular function be added to newborn screening protocols.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.