Evidence map›Paper›PMID 34658785›Full record

ArticleFrontiers in molecular neuroscience2021

Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer's Disease in Amyloid Precursor Protein/Presenilin 1 Mice.

Qing Zeng, Qin Fang, Xincai Zhou, Hongfa Yang, Yang Dou, Wenhao Zhang, Pu Gong, Xianfang Rong

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07353606 (Determination of Cofilin-2), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07353606 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Determination of Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Genetic Polymorphism and Change in Their Protein Levels Before and After Non-surgical Periodontal Therapy in Periodontitis Patients With and Without Coronary Heart Disease - An Interventional Study.

TypeinterventionalSponsorMeenakshi Ammal Dental College and HospitalRan2024 to 2026Enrolled84ConditionsPeriodontitis, Chronic Periodontitis (Disorder), Coronary Heart DiseaseArmsScaling and root planing
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Association between Alzheimer's disease andWorld journal of biological chemistry · 2025
    Article
  3. Alzheimer's Disease andLife (Basel, Switzerland) · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qing ZengDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Qin FangDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Xincai ZhouDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Hongfa YangDepartment of Cardiology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Yang DouDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Wenhao ZhangDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Pu GongDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Xianfang RongDepartment of Stomatology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Jinan University · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence has shown a correlation between chronic periodontitis (CP) and Alzheimer's disease (AD). Nevertheless, there is still a lack of direct evidence, and especially key molecules to connect the two diseases. This study aims to investigate potential protein links between CP and AD within the inflammatory aspect. The hippocampus of CP model mice and controls were collected, and changes in protein expression were evaluated using two-dimensional differential in-gel electrophoresis (2D-DIGE) analysis combined with liquid chromatography tandem mass spectrometry. A total of 15 differentially expressed proteins were identified in CP model mice, as compared with the controls. Among them, S100-A9, transthyretin, Cofilin 2, peroxiredoxin 2, and lipocalin-2 were validated by Western blot according to their dual function both in inflammation and AD. Based on 2D-DIGE analysis, CP animal model had higher levels of S100-A9, Cofilin 2, peroxiredoxin 2, and lipocalin-2 compared to controls. The level of Cofilin 2, one of the well-established proteins in the pathology of AD, was strongly correlated with the time course of CP pathology, indicating a specific molecular correlation between CP and AD. Moreover, the

Indexed as

2D-DIGEAlzheimer’s diseasechronic periodontitisCofilin 2neuroinflammation

Identifiers

PMID34658785
PMCPMC8514664
OpenAlexW3204269508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.