Evidence map›Paper›PMID 34658711›Full record

ArticlePostepy dermatologii i alergologii2021

Jan Romantowski, Agnieszka Maciejewska, Joanna Polanska, Eliza Wasilewska, Krzysztof Specjalski, Marta Chełminska, Ewa Jassem, Marek Niedoszytko

Open access · goldAbstract read
In one paragraph

Article in Postepy dermatologii i alergologii, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jan RomantowskiDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.
Agnieszka MaciejewskaDepartment of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland.
Joanna PolanskaFaculty of Automatic Control, Electronics, and Computer Science, Silesian University of Technology, Katowice, Poland.
Eliza WasilewskaDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.
Krzysztof SpecjalskiDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.
Marta ChełminskaDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.
Ewa JassemDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.
Marek NiedoszytkoDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.
Gdańsk Medical University · PLSilesian University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAllergen-specific immunotherapy (AIT) is the core treatment in allergic rhinitis and asthma. Although widely used, some patients do not benefit from treatment and there is no efficacy objective marker.

aimTo define the profile of gene transcripts during the build-up phase of AIT and their comparison to the control group and then search for a viable efficacy marker in relation to patient symptoms. MATERIAL AND

methodsAIT was administered in 22 patients allergic to grass pollen. Analysis of 15 selected transcript expression was performed in whole blood samples taken before AIT (sample A) and after reaching the maintenance dose (sample B). The control group included 25 healthy volunteers (sample C). The primary endpoint was Relative Quantification. The gene expression analysis was followed by clinical evaluation with the use of Allergy Control Score (ACS).

resultsComparison between samples A and B of gene expression showed a significant increase in

conclusionsThere is a significant change in the expression of

Indexed as

allergenallergic rhinitisasthmamRNA

Identifiers

PMID34658711
PMCPMC8501422
OpenAlexW3203137146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.