Evidence map›Paper›PMID 34658624›Full record

ArticleInternational journal of tryptophan research : IJTR2021

Effects of Psychological and Physical Stress on Oxidative Stress, Serotonin, and Fatigue in Young Females Induced by Objective Structured Clinical Examination: Pilot Study of u-8-OHdG, u-5HT, and s-HHV-6.

Tadayuki Iida, Yasuhiro Ito, Miho Kanazashi, Susumu Murayama, Takashi Miyake, Yuki Yoshimaru, Asami Tatsumi, Satoko Ezoe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of tryptophan research : IJTR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. F1000Research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Tadayuki IidaDepartment of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Mihara, Japan.ORCID https://orcid.org/0000-0003-4934-3576
Yasuhiro ItoSchool of Health Sciences, Fujita Health University, Toyoake, Aichi, Japan.
Miho KanazashiDepartment of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Mihara, Japan.
Susumu MurayamaDepartment of Physical Therapy, Hospital of Shiromachi, Mihara, Hiroshima, Japan.
Takashi MiyakeDepartment of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Japan.
Yuki YoshimaruHiroshima City Rehabilitation Hospital, Asaminami, Japan.
Asami TatsumiDepartment of Nursing, University of Human Environments, Obu, Aichi, Japan.
Satoko EzoeHealth Service Center Izumo, Shimane University, Izumo, Japan.
Prefectural University of Hiroshima · JPFujita Health University · JPHiroshima Prefectural Rehabilitation Center · JPShimane University · JPThe University of Osaka · JPUniversity of Human Environments · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo establish a method to prevent and manage fatigue caused by psychological and physical stress in young females, early detection factors, such as understanding of fatigue and causes of psychological and physical stress, as well as a review of early management of psychiatric disease, are important. With increasing knowledge regarding the diverse causes of stress, it is important to select biomarkers with consideration of the types of stress burden and mechanisms underlying the development of physical symptoms. The methods used to search for stress characteristics is an issue that needs to be addressed. However, consensus regarding objective assessment methods for impaired mental health is lacking.

methodsWe examined the effects of an objective structured clinical examination (OSCE), considered to be a uniform source of psychological and physical stress, on biomarkers of oxidative stress and fatigue in 16 third-year female medical university students (21.3 ± 2.1 years old) in Japan with a normal menstrual cycle. A self-administered questionnaire consisting of Zung's Self-rating Depression Scale (SDS) and State-Trait Anxiety Inventory (STAI) was used to assess subjective stress. Furthermore, stress-related biomarkers (urinary 8-hydroxy-2'-deoxyguanosine [u-8-OHdG], urinary 5-hydroxytryptamine [u-5-HT], and salivary human herpesvirus-6 [s-HHV-6]) were examined at 1 month, 1 week, and 1 day before, and 1 week after the OSCE.

resultsThe results indicated that the OSCE did not have effects on u-8-OHdG, a biomarker of oxidative stress. However, u-5-HT and s-HHV-6 were found to be elevated in examinations performed prior to the OSCE.

conclusionsThe present findings suggest that u-5-HT and s-HHV-6 levels can be used for objective assessment of mental and physical fatigue in young females, including that produced not only by knowledge regarding an upcoming OSCE, but also by skill and attitude aspects related to that examination.

Indexed as

objective structured clinical examinationSDSs-HHV-6STAIu-5-HTu-8-OHdG

Identifiers

PMID34658624
PMCPMC8512239
OpenAlexW3206390603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.