In Vitro and In Vivo Comparison of Hemoglobin and Electrolytes Following the Collection of Cell Saver Blood Washed with Either Normal Saline or Plasma-Lyte A.

Jill M Cholette, Hannah L McRae, Ron Angona, Christine Cahill, Michael F Swartz, George M Alfieris, Majed A Refaai

Open access · greenAbstract readComparative Study

In one paragraph

Article in The journal of extra-corporeal technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 90% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

Human Platelets in Intravenous Fluids Probed by Raman Tweezers Spectroscopy.Analytical chemistry · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jill M CholetteDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

Hannah L McRaeDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

Ron AngonaDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

Christine CahillDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

Michael F SwartzDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

George M AlfierisDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

Majed A RefaaiDepartment of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York.

University of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell saver blood is typically washed with normal saline (NS); however, recent studies have reported decreased red blood cell hemolysis and increased platelet function when a more physiologic washing solution, such as Plasma-Lyte A (PL-A) is used. We evaluated the in vitro and in vivo effects of NS compared to PL-A as washing solutions for cell saver blood in pediatric cardiac surgery. Cell saver blood was re-infused for up to 24 hours post-collection. Laboratory and clinical data were collected from infants receiving cell saver washed with either NS (

Indexed as

ElectrolytesHemoglobinsSaline SolutionErythrocytesHumansInfantElectrolytesHemoglobinsPlasmalyte ASaline Solutioncardiopulmonary bypasscell saverhemoglobinhemolysisrenal function

Identifiers

PMID34658415

DOI10.1182/ject-2100018

PMCPMC8499643

OpenAlexW3207794037

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.