Evidence map›Paper›PMID 34658359›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Autologous stem cell transplantation improves outcomes of patients with multiple myeloma receiving proteasome inhibitors and lenalidomide treatment].

X Ning, X Wei, X Guo, Q Wei, F Huang, Z Fan, N Xu, J Sun, R Feng, Q Liu and 1 more

Abstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

X NingDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
X WeiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
X GuoDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Q WeiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
F HuangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z FanDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
N XuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
J SunDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
R FengDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Q LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Y WeiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of autologous stem cell transplantation (ASCT) on treatment response and survival outcomes in patients with newly diagnosed multiple myeloma (MM) receiving treatments with proteasome inhibitors and lenalidomide.

methodsWe retrospectively collected the clinical data of newly diagnosed MM patients, who were eligible for ASCT and received proteasome inhibitors or lenalidomide-based treatment in our hospital from January, 2015 to December, 2019. The patients were divided into transplantation group and non-transplantation group, and in transplantation group, the patients received 4 to 6 courses of induction therapy with proteasome inhibitors or lenalidomide before ASCT, while those in the non-transplantation group received more than 8 courses of induction and consolidation therapy with proteasome inhibitors or lenalidomide-based regimens. The therapeutic efficacy and survival outcomes of the patinets were compared between the two groups.

resultsA total of 105 patients were enrolled in the study, including 48 (45.7%) in transplantation group and 57 (54.3%) in non-transplantation group. The two groups were matched for gender, age and treatment response after 4 courses of induction therapy (

conclusionASCT can further improve the depth of remission and survival outcomes in patients with newly diagnosed MM receiving treatments with proteasome inhibitors and lenalidomide.

Indexed as

Hematopoietic Stem Cell TransplantationMultiple MyelomaHumansLenalidomideNeoplasm Recurrence, LocalProteasome InhibitorsRetrospective StudiesStem Cell TransplantationTransplantation, AutologousLenalidomideProteasome Inhibitorsautologous stem cell transplantationlenalidomidemultiple myelomaproteasome inhibitor

Identifiers

PMID34658359
PMCPMC8526324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.