ArticleACS nano2021
Plasmonic-Assisted Thermocyclizations in Living Cells Using Metal-Organic Framework Based Nanoreactors.
Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Seeded-Growth of ZIF-8 onto Magnetic Nanoparticles: Smart Nanocarriers with Ultrahigh Drug Loading for AMF-Triggered Release.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Gold Nanostars as Multifunctional Platforms in Cancer Imaging and Therapy: Toward Radiotheranostic Applications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Supramolecular Materials and Strategies for Bioorthogonal Chemical Transformations.Chemical reviews · 2025Review
- Clickable Polymer-Based Coatings for Modulating the Interaction of Metal-Organic Framework Nanocrystals with Living Cells.ACS applied materials & interfaces · 2025Article
- Thermoplasmonic Effect Enables Indirect ON-OFF Control over the Z-E Isomerization of Azobenzene-Based Photoswitch.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Light-Responsive Nanoantennas Integrated into Nanoscale Metal-Organic Frameworks for Photothermal Drug Delivery.Small science · 2024Article
- Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis.Nature communications · 2024Article
- Ultrathin covalent organic overlayers on metal nanocrystals for highly selective plasmonic photocatalysis.Nature communications · 2023Article
- Inorganic nanoparticles as scaffolds for bioorthogonal catalysts.Advanced drug delivery reviews · 2023Review
- Nanosized metal-organic frameworks as unique platforms for bioapplications.Chemical communications (Cambridge, England) · 2023Review
- High-yield halide-assisted synthesis of metal-organic framework UiO-based nanocarriers.Nanoscale · 2022Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
We describe a microporous plasmonic nanoreactor to carry out designed near-infrared (NIR)-driven photothermal cyclizations inside living cells. As a proof of concept, we chose an intramolecular cyclization that is based on the nucleophilic attack of a pyridine onto an electrophilic carbon, a process that requires high activation energies and is typically achieved in bulk solution by heating at ∼90 °C. The core-shell nanoreactor (NR) has been designed to include a gold nanostar core, which is embedded within a metal-organic framework (MOF) based on a polymer-stabilized zeolitic imidazole framework-8 (ZIF-8). Once accumulated inside living cells, the MOF-based cloak of NRs allows an efficient diffusion of reactants into the plasmonic chamber, where they undergo the transformation upon near-IR illumination. The photothermal-driven reaction enables the intracellular generation of cyclic fluorescent products that can be tracked using fluorescence microscopy. The strategy may find different type of applications, such as for the spatio-temporal activation of prodrugs.
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