Evidence map›Paper›PMID 34658167›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Targeted Anti-Tumor Immunotherapy Using Tumor Infiltrating Cells.

Yifan Xie, Feng Xie, Lei Zhang, Xiaoxue Zhou, Jun Huang, Fangwei Wang, Jin Jin, Long Zhang, Linghui Zeng, Fangfang Zhou

Open access · goldAbstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. S100A9Journal of experimental & clinical cancer research : CR · 2024
    Article
  15. Review
  16. Article
  17. The RNA mFrontiers in immunology · 2024
    Review
  18. Article
  19. Heliyon · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yifan XieSchool of Medicine, Zhejiang University City College, Hangzhou, 310015, China.
Feng XieInstitutes of Biology and Medical Science, Soochow University, Suzhou, 215123, P. R. China.
Lei ZhangDepartment of Orthopaedic Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Rui'an, 325200, China.
Xiaoxue ZhouMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Jun HuangMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Fangwei WangMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Jin JinMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Long ZhangMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Linghui ZengSchool of Medicine, Zhejiang University City College, Hangzhou, 310015, China.
Fangfang ZhouInstitutes of Biology and Medical Science, Soochow University, Suzhou, 215123, P. R. China.ORCID 0000-0003-1870-7584
Zhejiang University · CNSoochow University · CNWenzhou Medical University · CN

Funding

Jiangsu Provincial Key Research and Development Program 19KJA5500003Ministry of Science and Technology 2016YFA0502500National Natural Science Foundation of China 31571460National Natural Science Foundation of China 31671457National Natural Science Foundation of China 31701232National Natural Science Foundation of China 31871405National Natural Science Foundation of China 31925013National Natural Science Foundation of China 82041009National Natural Science Foundation of China 91753139National Natural Science Foundation of China U20A20393Natural Science Foundation of Jiangsu Province BK20180043Natural Science Foundation of Zhejiang Province LBY21H060001Natural Science Foundation of Zhejiang Province LD19C070001Natural Science Foundation of Zhejiang Province LTY21H160001Priority Academic Program Development of Jiangsu Higher Education InstitutionsScience and Technology Plan Project of Suzhouthe medical and health research project of zhejiang province 2020RC115
6 · The paper itself

Abstract

In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti-tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor-infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti-tumor immune response to certain groups of patients. Herein, the recent research progress on tumor-infiltrating B cells and T cells, including CD8

Indexed as

HumansImmunotherapyLymphocytes, Tumor-InfiltratingNeoplasmsTumor Microenvironmentanti-tumor immunityanti-tumor therapyB cellsCD4+ T cellsCD8+ T cellsT-cell exhaustiontumor immunotherapytumor microenvironment

Identifiers

PMID34658167
PMCPMC8596143
OpenAlexW3205309803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.