Evidence map›Paper›PMID 34657982›Full record

ArticleIntensive care medicine experimental2021

Data automated bag breathing unit for COVID-19 ventilator shortages.

Aleksandra B Gruslova, Nitesh Katta, Andrew G Cabe, Scott F Jenney, Jonathan W Valvano, Tim B Phillips, Austin B McElroy, Robert K LaSalle, Aydin Zahedivash, Van N Truskett and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Aleksandra B GruslovaDepartment of Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, DTL 5.532U, San Antonio, TX, 78229, USA. gruslova@uthscsa.edu.ORCID http://orcid.org/0000-0003-3358-7015
Nitesh KattaBeckman Laser Institute, The University of California Irvine, Irvine, CA, USA.
Andrew G CabeDepartment of Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, DTL 5.532U, San Antonio, TX, 78229, USA.
Scott F JenneyUT Austin Cockrell School of Engineering, The University of Texas, Austin, TX, USA.
Jonathan W ValvanoUT Austin Cockrell School of Engineering, The University of Texas, Austin, TX, USA.
Tim B PhillipsUT Austin Cockrell School of Engineering, The University of Texas, Austin, TX, USA.
Austin B McElroyUT Austin Cockrell School of Engineering, The University of Texas, Austin, TX, USA.
Robert K LaSalleThermoTek, Inc, Flower Mound, TX, USA.
Aydin ZahedivashUT Austin Cockrell School of Engineering, The University of Texas, Austin, TX, USA.
Van N TruskettUT Austin Cockrell School of Engineering, The University of Texas, Austin, TX, USA.
Nishi ViswanathanDell Medical School, UT Austin, Austin, TX, USA.
Marc D FeldmanDepartment of Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, DTL 5.532U, San Antonio, TX, 78229, USA.
Richard B WettsteinSchool of Health Professions, UT Health San Antonio, San Antonio, TX, USA.
Thomas E MilnerBeckman Laser Institute, The University of California Irvine, Irvine, CA, USA.
Stephen DerdakSchool of Health Professions, UT Health San Antonio, San Antonio, TX, USA.
The University of Texas at Austin · USThe University of Texas Health Science Center at San Antonio · USUniversity of California, Irvine · USThermoTek (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic has caused a global mechanical ventilator shortage for treatment of severe acute respiratory failure. Development of novel breathing devices has been proposed as a low cost, rapid solution when full-featured ventilators are unavailable. Here we report the design, bench testing and preclinical results for an 'Automated Bag Breathing Unit' (ABBU). Output parameters were validated with mechanical test lungs followed by animal model testing.

resultsThe ABBU design uses a programmable motor-driven wheel assembled for adult resuscitation bag-valve compression. ABBU can control tidal volume (200-800 ml), respiratory rate (10-40 bpm), inspiratory time (0.5-1.5 s), assist pressure sensing (- 1 to - 20 cm H

conclusionsABBU provides oxygenation and ventilation across a range of parameter settings that may potentially provide a low-cost solution to ventilator shortages. A clinical trial is necessary to establish safety and efficacy in adult patients with diverse etiologies of respiratory failure.

Indexed as

ABBUAcute respiratory distress syndromeBag valve resuscitatorCOVID-19Emergency resuscitatorLung injuryVentilator shortage

Identifiers

PMID34657982
PMCPMC8520856
OpenAlexW3207405978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.