ArticleJournal of epidemiology2023
Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study.
Article in Journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Clinical guidelines on physical activity and exercise therapy for Chinese adults with type 2 diabetes: A clinical practice guideline from the Chinese Society of Endocrinology.Journal of sport and health science · 2026Guideline
- Sedentary behavior and risk of chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2025Pooled it
- The optimal exercise modality and intensity for hemodialysis patients incorporating Bayesian network meta-analysis and systematic review.Frontiers in physiology · 2022Pooled it
- Differential dose-response associations of leisure-time and non-leisure-time physical activity with perceived stress in middle-aged and older adults.Scientific reports · 2026Article
- Epidemiology of cardiovascular-kidney-metabolic syndrome.Nature reviews. Nephrology · 2026Review
- Impact of leisure-time and daily life physical activity on chronic kidney disease in individuals with type 2 diabetes: The Fukuoka Diabetes Registry.Clinical and experimental nephrology · 2026Article
- The Mediating Effect of 24-Hour Movement Behaviors on Mortality Risk in Chronic Kidney Disease: A Compositional Mediation and Life Expectancy Analysis.Journal of physical activity & health · 2026Article
- Sedentary behavior as an emerging risk factor for chronic kidney disease: a narrative review.Clinical and experimental nephrology · 2026Review
- Association between job characteristics and kidney function among men: a cross-sectional analysis of the Rafsanjan cohort study.BMC nephrology · 2025Article
- Impact of kidney function and leisure activities on disability risk among community-dwelling older adults.Clinical and experimental nephrology · 2025Article
- The Aging Kidney and Exercise Training Study: protocol for a randomized controlled trial within cohorts (TwiCs) study.BMC nephrology · 2025Article
- Association between impaired sensitivity to thyroid hormones and sedentary behavior: a cross-sectional study.Frontiers in medicine · 2025Article
- Associations between Physical Activity, Sedentary Time, and Locomotive Syndrome Differ by Age and Sex: A Cross-sectional Study.Physical therapy research · 2025Article
- Article
- Association of aerobic and muscle-strengthening physical activity with chronic kidney disease in participants with hypertension.Clinical hypertension · 2024Article
- Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study.Clinical epigenetics · 2024Article
- Impact of moderate to vigorous intensity physical activity on change in renal function in patients after acute myocardial infarction.Heart and vessels · 2024Observational
- Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study.Cancer science · 2024Article
- Associations of accelerometer-measured physical activity and sedentary time with renal function and chronic kidney disease: a national population-based study.Frontiers in endocrinology · 2024Article
- High physical activity alleviates the adverse effect of higher sedentary time on the incidence of chronic kidney disease.Journal of cachexia, sarcopenia and muscle · 2023Article
Corrections and comments
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Authors and funding
31 authors at 14 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.
methodsWe examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m
resultsAfter adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68-0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52-2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.
conclusionThese findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.