Evidence map›Paper›PMID 34657825›Full record

Trial reportEBioMedicine2021

Outcomes of a smartphone-based application with live health-coaching post-percutaneous coronary intervention.

Kaavya Paruchuri, Phoebe Finneran, Nicholas A Marston, Emma W Healy, John Andreo, Ryan Lynch, Alexander J Blood, Maeve Jones-O'Connor, Bradley Lander, Noreen Kelly and 4 more

Registry-linked trialOpen access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in EBioMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03416920 (A Smartphone-based Application Post-myocardial Infarction to Manage Cardiovascular Disease Risk), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03416920 nacompletednot on this map

A Smartphone-based Application Post-myocardial Infarction to Manage Cardiovascular Disease Risk

TypeinterventionalSponsorMassachusetts General HospitalRan2018 to 2019Enrolled167ConditionsPercutaneous Coronary InterventionArmsWellframe
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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  12. High-Intensity Statin Use Among Patients With Atherosclerosis in the U.S.Journal of the American College of Cardiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Kaavya ParuchuriCardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN 3.184, Boston, MA 02114, United States; Cardiovascular Disease Prevention Center, Massachusetts General Hospital, Boston, MA, United States; Department of Medicine, Harvard Medical School, Boston, MA, United States; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, United States.
Phoebe FinneranCardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN 3.184, Boston, MA 02114, United States.
Nicholas A MarstonDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA, United States.
Emma W HealyCardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN 3.184, Boston, MA 02114, United States; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
John AndreoDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA, United States.
Ryan LynchDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA, United States.
Alexander J BloodDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA, United States.
Maeve Jones-O'ConnorCardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN 3.184, Boston, MA 02114, United States; Department of Medicine, Harvard Medical School, Boston, MA, United States.
Bradley LanderDivision of Cardiology, Columbia University Irving Medical Center - New York Presbyterian Hospital, New York, NY, United States.
Noreen KellySanger Heart and Vascular Institute, Atrium Health, Charlotte, NC, United States.
Maria T VivaldiCardiovascular Disease Prevention Center, Massachusetts General Hospital, Boston, MA, United States; Department of Medicine, Harvard Medical School, Boston, MA, United States.
Kate TraynorCardiovascular Disease Prevention Center, Massachusetts General Hospital, Boston, MA, United States.
Stephen WiviottDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA, United States.
Pradeep NatarajanCardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN 3.184, Boston, MA 02114, United States; Cardiovascular Disease Prevention Center, Massachusetts General Hospital, Boston, MA, United States; Department of Medicine, Harvard Medical School, Boston, MA, United States; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, United States. Electronic address: pnatarajan@mgh.harvard.edu.
Brigham and Women's Hospital · USMassachusetts General Hospital · USBroad Institute · USHarvard University · USLevine Cancer Institute · USNewYork–Presbyterian Hospital · US

Funding

MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Clonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9M
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9M
Whole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7M
Discovery and Application of Germline and Somatic Mutations for Risk Prediction and Personalized Therapy to Prevent Recurrent Myocardial InfarctionK08HL153950 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARSTON, NICHOLAS · 2020 to 2024
$647k
NHLBI NIH HHS K08 HL153950NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS T32 HL007208
6 · The paper itself

Abstract

backgroundThe interval between inpatient hospitalization for symptomatic coronary artery disease (CAD) and post-discharge office consultation is a vulnerable period for adverse events.

methodsContent was customized on a smartphone app-based platform for hospitalized patients receiving percutaneous coronary intervention (PCI) which included education, tracking, reminders and live health coaches. We conducted a single-arm open-label pilot study of the app at two academic medical centers in a single health system, with subjects enrolled 02/2018-05/2019 and 1:3 propensity-matched historical controls from 01/2015-12/2017. To evaluate feasibility and efficacy, we assessed 30-day hospital readmission (primary), outpatient cardiovascular follow-up, and cardiac rehabilitation (CR) enrollment as recorded in the health system. Outcomes were assessed by Cox Proportional Hazards model.

findings118 of 324 eligible (36·4%) 21-85 year-old patients who underwent PCI for symptomatic CAD who owned a smartphone or tablet enrolled. Mean age was 62.5 (9·7) years, 87 (73·7%) were male, 40 of 118 (33·9%) had type 2 diabetes mellitus, 68 (57·6%) enrolled underwent PCI for MI and 59 (50·0%) had previously known CAD; demographics were similar among matched historical controls. No significant difference existed in all-cause readmission within 30 days (8·5% app vs 9·6% control, ARR -1.1% absolute difference, 95% CI -7·1-4·8, p = 0·699) or 90 days (16·1% app vs 19·5% control, p = 0.394). Rates of both 90-day CR enrollment (HR 1·99, 95% CI 1·30-3·06) and 1-month cardiovascular follow up (HR 1·83, 95% CI 1·43-2·34) were greater with the app. Weekly engagement at 30- and 90-days, as measured by percentage of weeks with at least one day of completion of tasks, was mean (SD) 73·5% (33·9%) and 63·5% (40·3%). Spearman correlation analyses indicated similar engagement across age, sex, and cardiovascular risk factors. INTERPRETATIONS: A post-PCI smartphone app with live health coaches yielded similarly high engagement across demographics and safely increased attendance in cardiac rehabilitation. Larger prospective randomized controlled trials are necessary to test whether this app improves cardiovascular outcomes following PCI.

fundingNational Institutes of Health, Boston Scientific. CLINICAL

trial registrationNCT03416920 (https://clinicaltrials.gov/ct2/show/NCT03416920).

Indexed as

AdultAgedAged, 80 and overCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleHumansMaleMentoringMiddle AgedMobile ApplicationsPatient DischargePercutaneous Coronary InterventionPilot ProjectsSmartphoneAppsDigital healthOutcomesSmartphone

Identifiers

PMID34657825
PMCPMC8577401
OpenAlexW3205027247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.