Evidence map›Paper›PMID 34657571›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Shaping longevity early in life: developmental ROS and H3K4me3 set the clock.

Bryndon J Oleson, Daphne Bazopoulou, Ursula Jakob

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Lactate promotes longevity through redox-driven lipid remodeling inbioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Simulating immunosuppressive mechanism ofFrontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bryndon J OlesonDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, USA.
Daphne BazopoulouDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, USA.
Ursula JakobDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, USA.

Funding

Research Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4M
Role of Molecular Chaperones in Stress Response and DiseaseR35GM122506 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ursula H. Jakob · 2017 to 2026
$6.8M
Investigation of developmental peroxide generation as an important lifespan-deterR21AG046799 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAKOB, URSULA H. · 2014 to 2015
$421k
NIA NIH HHS R21 AG046799NIA NIH HHS T32 AG000114NIGMS NIH HHS R35 GM122506
6 · The paper itself

Abstract

Studies in

Indexed as

Caenorhabditis elegans ProteinsLongevityAgingAnimalsCaenorhabditis elegansHistonesOxidative StressReactive Oxygen SpeciesCaenorhabditis elegans Proteinshistone H3 trimethyl Lys4HistonesReactive Oxygen SpeciesAgingepigeneticsh3k4me3hormesislongevityreactive oxygen speciesredox

Identifiers

PMID34657571
PMCPMC8794500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.