ArticleHypertension (Dallas, Tex. : 1979)2021
First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension.
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Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial.Nature medicine · 2026Trial
- Beyond the pump: integrating the heart's endocrine function into early medical education.Medical education online · 2026Review
- Beyond biomarkers: designer natriuretic peptides and cGMP centered therapies for cardiorenal and cardiometabolic protection in chronic heart failure.Internal and emergency medicine · 2026Review
- Metabolomics and Precision Medicine in Resistant Hypertension: Pathophysiological Insights, Biomarker Discovery, and Translational Strategies.International journal of hypertension · 2026Review
- Inhibiting atrial natriuretic peptide clearance reduces myocardial fibrosis and improves cardiac function in diabetic rats.European heart journal open · 2025Article
- The Balance Between the Natriuretic Peptides and the Renin-Angiotensin-Aldosterone System in the Preservation of Ideal Cardiovascular Health.Journal of clinical medicine · 2025Review
- Cross talk on therapeutic strategies: natriuretic peptides and inhibiting neprilysin in hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Porous silicon and silica carriers for delivery of peptide therapeutics.Drug delivery and translational research · 2024Review
- Discovery of small molecule guanylyl cyclase B receptor positive allosteric modulators.PNAS nexus · 2024Article
- MANP in Hypertension With Metabolic Syndrome: Proof-of-Concept Study of Natriuretic Peptide-Based Therapy for Cardiometabolic Disease.JACC. Basic to translational science · 2024Article
- Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.American journal of physiology. Heart and circulatory physiology · 2023Article
- The Natriuretic Peptide System: A Single Entity, Pleiotropic Effects.International journal of molecular sciences · 2023Review
- zDHHC9 Regulates Cardiomyocyte Rab3a Activity and Atrial Natriuretic Peptide Secretion Through Palmitoylation of Rab3gap1.JACC. Basic to translational science · 2023Article
- Natriuretic Peptides: It Is Time for Guided Therapeutic Strategies Based on Their Molecular Mechanisms.International journal of molecular sciences · 2023Review
- Natriuretic peptide pathways in heart failure: further therapeutic possibilities.Cardiovascular research · 2023Article
- MANP Activation Of The cGMP Inhibits Aldosterone Via PDE2 And CYP11B2 In H295R Cells And In Mice.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Purification, characterization, and preliminary serial crystallography diffraction advances structure determination of full-length human particulate guanylyl cyclase A receptor.Scientific reports · 2022Article
- Natriuretic Peptide-Based Novel Therapeutics: Long Journeys of Drug Developments Optimized for Disease States.Biology · 2022Review
- Effects of elevation of ANP and its deficiency on cardiorenal function.JCI insight · 2022Article
- MANP (M-Atrial Natriuretic Peptide) Reduces Blood Pressure and Furosemide-Induced Increase in Aldosterone in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Horng H ChenCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN (H.H.C., S.R.I., J.S., J.C.B.).ORCID 0000-0002-2315-0330
Siu-Hin WanDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (S.-H.W.).
Seethalakshmi R IyerCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN (H.H.C., S.R.I., J.S., J.C.B.).
Valentina CannoneDepartment of Internal Medicine, University of Parma, Parma, Italy (V.C.).
S Jeson SangaralinghamCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN (H.H.C., S.R.I., J.S., J.C.B.).ORCID 0000-0002-3967-8703
Joel NuetelIntegrium, Tustin, CA (J.N.).
John C BurnettCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN (H.H.C., S.R.I., J.S., J.C.B.).
Mayo Clinic · USMillennium Engineering and Integration (United States) · USThe University of Texas Southwestern Medical Center · USUniversity of Parma · IT
Funding
Human Cardiorenal SyndromeR01HL084155 · NHLBI · MAYO CLINIC ROCHESTER · PI HORNG H CHEN · 2009 to 2026
$5.5MNovel Peptide Therapeutics for HypertensionR01HL136340 · NHLBI · MAYO CLINIC ROCHESTER · PI BURNETT, JOHN C · 2018 to 2021
$2.5MNHLBI NIH HHS R01 HL084155NHLBI NIH HHS R01 HL136340
Abstract
[Figure: see text].
Indexed as
AdultAgedAldosteroneAtrial Natriuretic FactorBlood PressureFemaleHumansHypertensionMaleMiddle AgedNatriuresisSodiumAldosteroneAtrial Natriuretic FactorSodiumaldosteroneblood pressurecardiovascular diseaseguanylyl cyclasenatriuresis
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.