Evidence map›Paper›PMID 34657443›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice.

Jie Zhang, Ximing Wang, Yu Cui, Shan Jiang, Jin Wei, Jenna Chan, Anish Thalakola, Thanh Le, Lan Xu, Liang Zhao and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Diabetic nephropathy: Role of nitric oxide.Nitric oxide : biology and chemistry · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Tubuloglomerular feedback: a key player in obesity-associated kidney injury.American journal of physiology. Renal physiology · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Jie Zhang *Department of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.ORCID 0000-0001-6717-4118
Ximing Wang *Department of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Yu Cui *Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (Y.C., L.Z.).
Shan JiangDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Jin WeiDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Jenna ChanDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Anish ThalakolaDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Thanh LeDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Lan XuCollege of Medicine, College of Public Health (L.X.), University of South Florida, Tampa.
Liang ZhaoKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (Y.C., L.Z.).
Lei WangDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
Kun JiangDepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center, Research Institute, Tampa, FL (K.J.).
Feng ChengDepartment of Pharmaceutical Science, College of Pharmacy (F.C.), University of South Florida, Tampa.
Trushar PatelDepartment of Urology (T.P.), University of South Florida, Tampa.
Jacentha BuggsAdvanced Organ Disease and Transplantation Institute, Tampa General Hospital, FL (J.B.).
Volker VallonDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA (V.V.).
Ruisheng LiuDepartment of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
J.P. Morgan · GBUniversity of South Florida · USFirst Affiliated Hospital Zhejiang University · CNMoffitt Cancer Center · USTampa General Hospital · USUniversity of California San Diego · US

Funding

Glomerular and Tubular Function in the Diabetic KidneyR01DK112042 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SCOTT Culver THOMSON, Volker Vallon · 2017 to 2026
$4.1M
The Contribution of Kidney Disease to Age-Associated Cognitive DeclineRF1AG061296 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MAHER, PAMELA ANNE · 2019 to 2019
$3.2M
Role of tubuloglomerular feedback in the development of hypertension in diabetesR01HL142814 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2019 to 2022
$2.4M
Macula densa NOS1 and transplanted renal graft functionR01DK122050 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LEI · 2020 to 2024
$1.6M
Renal hemodynamics and hypertension during pregnancyR01HL137987 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2018 to 2021
$1.6M
Tubuloglomerular feedback and salt-sensitive hypertensionR01DK098582 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2013 to 2016
$1.3M
Primary cilia and modulation of the renal microcirculationR01DK099276 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2014 to 2017
$980k
NHLBI NIH HHS R01 HL137987NHLBI NIH HHS R01 HL142814NIA NIH HHS RF1 AG061296NIDDK NIH HHS R01 DK098582NIDDK NIH HHS R01 DK099276NIDDK NIH HHS R01 DK112042NIDDK NIH HHS R01 DK122050
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsBlood PressureGlomerular Filtration RateHemodynamicsKidney GlomerulusMiceMice, KnockoutNitric OxideNitric Oxide Synthase Type INitric OxideNitric Oxide Synthase Type Idiabetes mellitusglomerular filtration ratehemodynamicshypertensionkidneynitric oxidenitric oxide synthase

Identifiers

PMID34657443
PMCPMC8651058
OpenAlexW3205356442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.