Evidence map›Paper›PMID 34657379›Full record

ArticleESC heart failure2021

Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community.

Shashwati Dutta, Desmond Li, Andy Wang, Mark Ishak, Kristina Cook, Melissa Farnham, Hasthi Dissanayake, Peter Cistulli, Imre Hunyor, Renping Liu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Immunometabolism at the Heart of Cardiovascular Disease.JACC. Basic to translational science · 2023
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 2 countries.

Shashwati DuttaHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Desmond LiHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Andy WangNorthern Clinical School, Sydney Medical School, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Mark IshakHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Kristina CookNorthern Clinical School, Sydney Medical School, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Melissa FarnhamHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Hasthi DissanayakeNorthern Clinical School, Sydney Medical School, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Peter CistulliNorthern Clinical School, Sydney Medical School, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Imre HunyorDepartment of Cardiology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia.
Renping LiuHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Ian WilcoxDepartment of Cardiology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia.
Yen Chin KoayHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Jean YangSchool of Mathematics and Statistics, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Sean LalPrecision Cardiovascular Laboratory, The University of Sydney, Camperdown, Sydney, NSW, Australia.
John F O'SullivanHeart Research Institute, Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.ORCID 0000-0001-8016-5128
The University of Sydney · AU

Funding

THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8M
Metabolomic predictors of insulin resistance and diabetesR01DK081572 · NIDDK · VANDERBILT UNIVERSITY · PI CLISH, CLARY B, GERSZTEN, ROBERT E · 2008 to 2025
$9.3M
SNP HEALTH ASSOCIATION RESOURCE (SHARE)N02HL64278 · NHLBI · PI CHIN, SIANG · 2007 to 2007
$9.2M
SLEEP AND ENTRAINMENT OF SCN FUNCTIONR01HL064278 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2002
$871k
Hepatic Responses to Pulmonary InfectionsF32HL104853 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHINTHRAJAH, REBECCA SHARON · 2011 to 2011
$65k
NHLBI NIH HHS HHSN268201300008CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS N01HC25195NHLBI NIH HHS N02 HL64278NIDDK NIH HHS R01 DK081572
6 · The paper itself

Abstract

aimsSleep apnoea and congestive heart failure (CHF) commonly co-exist, but their interaction is unclear. Metabolomics may clarify their interaction and relationships to outcome. METHODS AND

resultsWe assayed 372 circulating metabolites and lipids in 1919 and 1524 participants of the Framingham Heart Study (FHS) (mean age 54 ± 10 years, 53% women) and Women's Health Initiative (WHI) (mean age 67 ± 7 years), respectively. We used linear and Cox regression to relate plasma concentrations of metabolites and lipids to echocardiographic parameters; CHF and its subtypes heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF); and sleep indices. Adenine dinucleotide phosphate (ADP) associated with left ventricular (LV) fractional shortening; phosphocreatine with LV wall thickness; lysosomal storage molecule sphingomyelin 18:2 with LV mass; and nicotine metabolite cotinine with time spent with an oxygen saturation less than 90% (β = 2.3 min, P = 2.3 × 10

conclusionsEnergetic metabolites were associated with cardiac function; energy- and lipid-storage metabolites with LV wall thickness and mass; plasma levels of nicotine metabolite cotinine were associated with increased time spent with a sleep oxygen saturation less than 90%, a clinically significant marker of outcome, indicating a significant hazard for smokers who have sleep apnoea.

Indexed as

Heart FailureSleep Apnea SyndromesAdultAgedEchocardiographyFemaleHeart VentriclesHumansMaleMiddle AgedStroke VolumeBiomarkerFraminghamHeart failureLipidMetaboliteMortalitySleep apnoea

Identifiers

PMID34657379
PMCPMC8712919
OpenAlexW3205217306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.