Evidence map›Paper›PMID 34657338›Full record

ArticleMolecular microbiology2021

Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira.

Lenka Fule, Ruben Halifa, Celia Fontana, Odile Sismeiro, Rachel Legendre, Hugo Varet, Jean-Yves Coppée, Gerald L Murray, Ben Adler, David R Hendrixson and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Lenka FuleInstitut Pasteur, Biology of Spirochetes Unit, Paris, France.
Ruben HalifaInstitut Pasteur, Biology of Spirochetes Unit, Paris, France.
Celia FontanaBoehringer Ingelheim Santé Animale, Saint Priest, France.
Odile SismeiroTranscriptome and Epigenome Platform, Biomics, Center for Technological Resources and Research (C2RT), Institut Pasteur, Paris, France.
Rachel LegendreTranscriptome and Epigenome Platform, Biomics, Center for Technological Resources and Research (C2RT), Institut Pasteur, Paris, France.
Hugo VaretTranscriptome and Epigenome Platform, Biomics, Center for Technological Resources and Research (C2RT), Institut Pasteur, Paris, France.
Jean-Yves CoppéeTranscriptome and Epigenome Platform, Biomics, Center for Technological Resources and Research (C2RT), Institut Pasteur, Paris, France.
Gerald L MurrayInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Ben AdlerInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
David R HendrixsonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Alejandro BuschiazzoPasteur International Unit, Integrative Microbiology of Zoonotic Agents, Institut Pasteur de Montevideo, Montevideo, Uruguay/Institut Pasteur, Paris, France.
Shuaiqi GuoMicrobial Sciences Institute & Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA.
Jun LiuMicrobial Sciences Institute & Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA.
Mathieu PicardeauInstitut Pasteur, Biology of Spirochetes Unit, Paris, France.ORCID 0000-0002-5338-5579
Institut Pasteur · FRDiscovery Institute · USMicrobial ID (United States) · USBoehringer Ingelheim (France) · FRInstitut Pasteur de Montevideo · UYThe University of Texas Southwestern Medical Center · US

Funding

Flagellar Motor Biogenesis in Polarly-Flagellated Bacterial PathogensR01AI065539 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI DAVID R HENDRIXSON · 2006 to 2026
$9.2M
Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6M
NIAID NIH HHS R01 AI065539NIAID NIH HHS R01 AI087946
6 · The paper itself

Abstract

Spirochetes can be distinguished from other bacteria by their spiral-shaped morphology and subpolar periplasmic flagella. This study focused on FlhF and FlhG, which control the spatial and numerical regulation of flagella in many exoflagellated bacteria, in the spirochete Leptospira. In contrast to flhF which seems to be essential in Leptospira, we demonstrated that flhG

Indexed as

Bacterial ProteinsCryoelectron MicroscopyFlagellaGene Expression ProfilingGene Expression Regulation, BacterialGenetic Complementation TestHumansLeptospiraLeptospirosisMonomeric GTP-Binding ProteinsMutationSpirochaetalesVirulenceBacterial ProteinsflhF protein, BacteriaMonomeric GTP-Binding ProteinsendoflagellumFlhGLeptospiramotilityspirochetes

Identifiers

PMID34657338
PMCPMC13155646
OpenAlexW3207250897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.