ArticleMagnetic resonance in medicine2022
Residual quadrupolar couplings observed in 7 Tesla deuterium MR spectra of skeletal muscle.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Deuterium metabolic imaging beyond the brain: mapping tissue metabolism across the body.Magma (New York, N.Y.) · 2026Review
- Development of a Double TunedNMR in biomedicine · 2025Article
- Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Deuterium brain imaging at 7T during DMagnetic resonance in medicine · 2023Article
- Residual quadrupolar couplings observed in 7 Tesla deuterium MR spectra of skeletal muscle.Magnetic resonance in medicine · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
purposeDeuterium metabolic imaging could potentially be used to investigate metabolism in skeletal muscle noninvasively. However, skeletal muscle is a tissue with a high degree of spatial organization. In this study, we investigated the effect of incomplete motional averaging on the naturally abundant deuterated water signal in 7 Tesla deuterium spectra of the lower leg muscles and the dependence on the angle between the muscle fibers and the main magnetic field B
methodsNatural abundance deuterium MRSI measurements of the right lower leg muscles were performed at 7 Tesla. Three subjects were scanned in a supine position, with the right leg parallel with the B
resultsWe observed splittings in the natural abundance deuterated water signal. The size of the splittings varied between different muscles in the lower leg but were mostly similar among subjects for each muscle. The splittings depended on the orientation of the muscle fibers with respect to the main magnetic field B
conclusionPartial molecular alignment in skeletal muscle leads to residual deuteron quadrupolar couplings in deuterated water, the size of which depends on the angle between the muscle fibers and B
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